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Pro- and anti-inflammatory cytokines in post-infarction left ventricular remodeling

Abstract : OBJECTIVES: Acute myocardial infarction (MI) leads to molecular, structural, geometric and functional changes in the heart during a process known as ventricular remodeling. Myocardial infarction is followed by an inflammatory response in which pro- and anti-inflammatory cytokines play a crucial role, particularly in left ventricular remodeling. This study aimed at evaluating serum concentrations of interleukin-8 (IL8), tumor-necrosis-factor-alpha (TNFα) and interleukin-10 (IL10), pro- and anti-inflammatory cytokines, and at correlating them with left ventricular remodeling as assessed by echocardiographic parameters. METHODS: In a case-control study 30 MI patients were compared with 30 healthy controls. Serum concentrations of IL8, TNFα and IL10 were measured on day 2 and day 30 post-MI by chemiluminescence immunoassay and correlated with echocardiographic parameters. RESULTS: There was an increase of IL8, and TNFα together with a decrease of IL10 at both time points. IL8 was negatively correlated with the left ventricular end-diastolic diameter (LVEDD) and positively with left ventricular systolic volume. IL10 was negatively correlated with LVEDD and left atrial volume 30days post-MI. CONCLUSION: The increase of pro-inflammatory cytokines TNFα and IL8 was accompanied by decreased anti-inflammatory IL10. This imbalance between pro- and anti-inflammatory cytokines might contribute to the progression of left ventricular remodeling and may lead to heart failure.
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Submitted on : Friday, January 20, 2017 - 10:34:01 AM
Last modification on : Thursday, August 25, 2022 - 9:14:34 AM




Sinda S Zarrouk-Mahjoub, Mariem Zaghdoudi, Z. Amira, H. Chebi, Neila Khabouchi, et al.. Pro- and anti-inflammatory cytokines in post-infarction left ventricular remodeling. International Journal of Cardiology, 2016, 221, pp.632-6. ⟨10.1016/j.ijcard.2016.07.073⟩. ⟨pasteur-01441740⟩



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