Correspondence Unusual recovery of respiratory chain complex-III deficiency upon G-tube feeding and a cocktail

Josef Finsterer (1) , Sinda Zarrouk-Mahjoub (2)

1 Krankenanstalt Rudolfstiftung
2 LR11IPT05 - Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory

With interest we read the article by Mori et al. about a 7 year old male with respiratory-chain complex-III-deficiency due to a 9 bpdeletion in the cytb gene, which initially manifested with failure to thrive, vomiting, diarrhea, constipation, weight-loss, fatigue, exerciseintolerance, muscle weakness, metabolic acidosis, and creatine-kinase elevation and who recovered almost completely by age 12 years [1]. We have the following comments and concerns

Mots clés: Respiratory chain; Mitochondrial DNA; Complex-III; Deletion; Recovery; Treatment

Domaines: Sciences du Vivant [q-bio]

Josef Finsterer, Sinda Zarrouk-Mahjoub. Correspondence Unusual recovery of respiratory chain complex-III deficiency upon G-tube feeding and a cocktail. Molecular Genetics and Metabolism Reports, 2016, ⟨10.1016/j.ymgmr.2016.04.005⟩. ⟨pasteur-01451510⟩