A method and server for predicting damaging missense mutations, Nat. Methods, vol.7, pp.248-257, 2010. ,
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation, Proc, 2013. ,
, Natl. Acad. Sci. U. S. A, vol.110, pp.7784-7793
Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification, DNA Repair (Amst), vol.43, pp.48-56, 2016. ,
The APOBEC-2 crystal structure and functional implications for the deaminase AID, Nature, vol.445, pp.447-51, 2007. ,
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2), Cell, vol.102, pp.565-75, 2000. ,
The anatomy and taxonomy of protein structure, Adv. Protein Chem, vol.34, pp.167-339, 1981. ,
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.2253-2261, 2014. ,
Separate domains of AID are required for somatic hypermutation and class-switch recombination, Nat. Immunol, vol.5, pp.707-712, 2004. ,
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.15866-71, 2008. ,
AID mutant analyses indicate requirement for class-switch-specific cofactors, Nat. Immunol, vol.4, pp.843-851, 2003. ,
Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland, Eur. J. Hum. Genet, 2016. ,
Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business, 2003. ,
, Trends Genet, vol.19, pp.207-223
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond, Nat. Rev. Immunol, vol.12, pp.517-548, 2012. ,
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts, Science, vol.296, pp.2033-2039, 2002. ,
Differential regulation of Sregion hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.1016-1040, 2014. ,
Regulation of Aicda expression and AID activity, Autoimmunity, vol.46, pp.83-101, 2013. ,
Noncoding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA, Cell, vol.161, pp.762-773, 2015. ,
Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase, J. Med, 2003. ,
, Dent. Sci, vol.50, pp.41-47
, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health