Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract.

Abstract : In the present study, the potential effect anti tumor and the chemical composition of different fractions of Gokshur was evaluated. Commonly known as puncture vine, it has been used for a long time in both the Indian and traditional Chinese medicine. It is popularly used as a remedy for fertility disorder in Ayurveda. Samples were collected during June-September 2014 in the Cap Bon (north east of the northern Tunisia). Different organs were separated and extracted by sequential process to compare and investigate their potential anti-tumor effect. For the first time, we report the antiproliferatif effect of leaves n-butannolic fraction against cancer cell lines. The better anti-tumor fraction (94.76±1.52%) has been detected and performed by RP-HPLC has shown a great peak area (5578.21Mau). Novel designed natural derivatives from Gokshur, a cyclotrisiloxane, major compound identified by GC-MS.
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Submitted on : Thursday, February 9, 2017 - 2:53:57 PM
Last modification on : Friday, October 11, 2019 - 8:22:39 PM

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Salwa Bouabdallah, Rabiaa-M Sghaier, Sawssen Selmi, Daycem Khlifi, Dhafer Laouini, et al.. Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract.. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2016, pp.279-85. ⟨10.1016/j.jchromb.2015.11.023 ⟩. ⟨pasteur-01463317⟩

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