Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract. - Archive ouverte HAL Access content directly
Journal Articles Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences Year : 2016

Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract.

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Abstract

In the present study, the potential effect anti tumor and the chemical composition of different fractions of Gokshur was evaluated. Commonly known as puncture vine, it has been used for a long time in both the Indian and traditional Chinese medicine. It is popularly used as a remedy for fertility disorder in Ayurveda. Samples were collected during June-September 2014 in the Cap Bon (north east of the northern Tunisia). Different organs were separated and extracted by sequential process to compare and investigate their potential anti-tumor effect. For the first time, we report the antiproliferatif effect of leaves n-butannolic fraction against cancer cell lines. The better anti-tumor fraction (94.76±1.52%) has been detected and performed by RP-HPLC has shown a great peak area (5578.21Mau). Novel designed natural derivatives from Gokshur, a cyclotrisiloxane, major compound identified by GC-MS.
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Dates and versions

pasteur-01463317 , version 1 (09-02-2017)

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Salwa Bouabdallah, Rabiaa-M Sghaier, Sawssen Selmi, Daycem Khlifi, Dhafer Laouini, et al.. Current approaches and challenges for chemical characterization of inhibitory effect against cancer cell line isolated from Gokshur extract.. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2016, pp.279-85. ⟨10.1016/j.jchromb.2015.11.023⟩. ⟨pasteur-01463317⟩
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