Abstract : With interest we read the article by Billing-Ross et al.
[1] about 193 patients with chronic fatigue syndrome
(CFS) diagnosed according to the Fukuda or Canadian
Consensus criteria and undergoing sequencing of the
mtDNA, the DePaul Symptom questionnaire and the
Medical Outcome Survey Short Form-36. The study
showed that CFS is associated with mtDNA haplogroups
J, U and H, that 8 mtDNA single nucleotide polymorphisms
(SNPs) were associated with 16 symptom categories,
and that three haplogroups were associated with
six symptom categories [1]. We have the following comments
and concerns
Josef Finsterer, Sinda Zarrouk-Mahjoub. Is chronic fatigue syndrome truly associated with haplogroups or mtDNA single nucleotide polymorphisms?. Journal of Translational Medicine, BioMed Central, 2016, pp.182. 〈10.1186/s12967-016-0939-0 〉. 〈pasteur-01467096〉
