Is chronic fatigue syndrome truly associated with haplogroups or mtDNA single nucleotide polymorphisms?

Abstract : With interest we read the article by Billing-Ross et al. [1] about 193 patients with chronic fatigue syndrome (CFS) diagnosed according to the Fukuda or Canadian Consensus criteria and undergoing sequencing of the mtDNA, the DePaul Symptom questionnaire and the Medical Outcome Survey Short Form-36. The study showed that CFS is associated with mtDNA haplogroups J, U and H, that 8 mtDNA single nucleotide polymorphisms (SNPs) were associated with 16 symptom categories, and that three haplogroups were associated with six symptom categories [1]. We have the following comments and concerns
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Josef Finsterer, Sinda Zarrouk-Mahjoub. Is chronic fatigue syndrome truly associated with haplogroups or mtDNA single nucleotide polymorphisms?. Journal of Translational Medicine, BioMed Central, 2016, pp.182. ⟨10.1186/s12967-016-0939-0 ⟩. ⟨pasteur-01467096⟩

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