Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

Résumé : BACKGROUND: The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low molecular mass cosubstrate absent in the host. In pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Thus, TryS qualifies as an attractive drug target candidate.
Type de document :
Article dans une revue
PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (4), pp.e0004617. 〈10.1371/journal.pntd.0004617〉
Liste complète des métadonnées

Littérature citée [68 références]  Voir  Masquer  Télécharger

https://hal-riip.archives-ouvertes.fr/pasteur-01498320
Contributeur : Mariella Botta <>
Soumis le : mardi 26 septembre 2017 - 17:05:17
Dernière modification le : jeudi 20 septembre 2018 - 13:56:06

Fichier

journal.pntd.0004617.pdf
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Diego Benítez, Andrea Medeiros, Lucía Fiestas, Esteban A Panozzo-Zenere, Franziska Maiwald, et al.. Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.. PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (4), pp.e0004617. 〈10.1371/journal.pntd.0004617〉. 〈pasteur-01498320〉

Partager

Métriques

Consultations de la notice

30

Téléchargements de fichiers

32