W. F. An and N. Tolliday, Cell-Based Assays for High-Throughput Screening, Molecular Biotechnology, vol.11, issue.5, pp.180-186, 2010.
DOI : 10.2174/1386207043328337

A. Asano, H. Jin, and T. Watanabe, Mouse Mx2 gene: organization, mRNA expression and the role of the interferon-response promoter in its regulation, Gene, vol.306, pp.105-113, 2003.
DOI : 10.1016/S0378-1119(03)00428-1

M. Bürgi, C. Prieto, M. Oggero, M. Bollati-fogolín, M. Etcheverrigaray et al., New reporter cell clones to determine the biological activity of human type I interferons, BMC Proceedings, vol.5, issue.Suppl 8, p.4, 2011.
DOI : 10.1006/jmbi.1999.3230

M. Bürgi, C. Prieto, M. Etcheverrigaray, R. Kratje, M. Oggero et al., WISH cell line: From the antiviral system to a novel reporter gene assay to test the potency of human IFN-?? and IFN-??, Journal of Immunological Methods, vol.381, issue.1-2, pp.70-74, 2012.
DOI : 10.1016/j.jim.2012.04.010

J. Banchereau and V. Pascual, Type I interferons in systemic lupus erythematosus and other autoinmune diseases, Inmunity, vol.25, pp.383-392, 2006.

A. Billiau, Interferon: The pathways of discovery, Cytokine & Growth Factor Reviews, vol.17, issue.5, pp.381-409, 2006.
DOI : 10.1016/j.cytogfr.2006.07.001

M. Bollati-fogolín and W. Müller, Virus free, cell-based assay for the quantification of murine type I interferons, Journal of Immunological Methods, vol.306, issue.1-2, pp.169-175, 2005.
DOI : 10.1016/j.jim.2005.08.005

E. C. Borden, T. F. Hogan, and J. G. Voelkel, Comparative antiproliferativa activity in vitro of natural interferons a and b for diploid and transformed human cell lines, Cancer Res, vol.42, pp.4948-4953, 1982.

C. Brideau, B. Gunter, B. Pikounis, and A. Liaw, Improved Statistical Methods for Hit Selection in High-Throughput Screening, Journal of Biomolecular Screening, vol.8, issue.6, pp.634-647, 2003.
DOI : 10.1080/01621459.1993.10476310

URL : http://journals.sagepub.com/doi/pdf/10.1177/1087057103258285

M. Entzeroth, H. Flotow, and P. Condron, Overview of high-throughput screening, Curr. Protoc. Pharmacol, vol.9, 2009.

M. W. Khalil, F. Sasse, H. Lünsdorf, Y. A. Elnakady, and H. Reincheinbach, Mechanism of Action of Tubulysin, an Antimitotic Peptide from Myxobacteria, ChemBioChem, vol.50, issue.4, pp.678-683, 2006.
DOI : 10.1016/0003-2697(72)90046-2

D. Kugel, J. E. Pulverer, M. Köster, H. Hauser, and P. Staeheli, Novel Nonviral Bioassays for Mouse Type I and Type III Interferon, Journal of Interferon & Cytokine Research, vol.31, issue.4, pp.345-349, 2011.
DOI : 10.1089/jir.2010.0079

URL : https://hzi.openrepository.com/hzi/bitstream/10033/142969/1/Kugel%20et%20al_final.pdf

L. Larocque, A. Bliu, R. Xu, A. Diress, W. J. Lin et al., Bioactivity Determination of Native and Variant Forms of Therapeutic Interferons, Journal of Biomedicine and Biotechnology, vol.19, issue.21, 2011.
DOI : 10.1155/2009/860761

C. B. Lopez and T. Hermesh, Systemic responses during local viral infections: type I IFNs sound the alarm, Current Opinion in Immunology, vol.23, issue.4, pp.498-499, 2011.
DOI : 10.1016/j.coi.2011.06.003

E. A. Martis, R. Radhakrishnan, and R. R. Badve, High-throughput screening: the hits and leads of drug discovery?an overview, J. Appl. Pharm. Sci, vol.1, pp.2-10, 2011.

A. Meager, Assays for Antiviral Activity, Cytokine Protocols, p.121, 2003.
DOI : 10.1385/1-59259-667-3:121

O. Meyer, Interferons and autoimmune disorders, Joint Bone Spine, vol.76, issue.5, pp.464-473, 2009.
DOI : 10.1016/j.jbspin.2009.03.012

K. P. Mishra, L. Ganju, M. Sairman, P. K. Banerjee, and R. C. Sawhney, A review of high throughput technology for the screening of natural products, Biomedicine & Pharmacotherapy, vol.62, issue.2, pp.94-98, 2008.
DOI : 10.1016/j.biopha.2007.06.012

K. Mowen and M. David, Regulation of STAT1 Nuclear Export by Jak1, Molecular and Cellular Biology, vol.20, issue.19, pp.7273-7281, 2000.
DOI : 10.1128/MCB.20.19.7273-7281.2000

B. C. Murray, M. T. Peterson, and R. A. Fecik, Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers, Nat. Prod. Rep., vol.109, issue.5, 2015.
DOI : 10.1021/cr900174j

N. I. Nechai, V. I. Potkin, R. V. Kaberdin, and V. L. Murashko, Reaction of 2-nitro-4-bromo-1,1 3,4-tetrachloro-1,3-butadiene with S-nucleophilic reagents, pp.65-70, 1997.

V. I. Potkin, R. V. Kaberdin, and Y. A. Ol-'dekop, Synthesis of 1-nitropentachloro-1, 3-butadiene and reaction with O-, N-, and bifunctional nucleophilic reagents, J. Org. Chem. USSR, vol.27, pp.48-54, 1991.

J. E. Pulverer, U. Rand, S. Lienenklaus, D. Kugel, N. Zietara et al., Temporal and Spatial Resolution of Type I and III Interferon Responses In Vivo, Journal of Virology, vol.84, issue.17, pp.8626-8638, 2010.
DOI : 10.1128/JVI.00303-10

U. Rand, M. Rinas, J. Schwerk, G. Nöhren, M. Linnes et al., Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response, Molecular Systems Biology, vol.634, 2012.
DOI : 10.1371/journal.pbio.1001249

URL : http://msb.embopress.org/content/msb/8/1/584.full.pdf

H. Reichenbach and G. Höfle, Myxobacteria as Producers of Secondary Metabolites, pp.149-179, 1999.
DOI : 10.1007/978-3-642-60250-4_9

K. H. Richards and A. Macdonald, Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production, Microbes and Infection, vol.13, issue.4, pp.291-302, 2011.
DOI : 10.1016/j.micinf.2010.12.007

F. Sasse, H. Steinmetz, G. Höfle, and H. Reichenbach, Antibiotics from gliding bacteria. No.61. Gephyronic Acid, a Novel Inhibitor of Eukaryotic Protein Synthesis from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties, and Mechanism of Action., The Journal of Antibiotics, vol.48, issue.1, pp.21-25, 1995.
DOI : 10.7164/antibiotics.48.21

F. Sasse, H. Steinmetz, J. Heil, G. Höfle, and H. Reichenbach, Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties., The Journal of Antibiotics, vol.53, issue.9, pp.879-885, 2000.
DOI : 10.7164/antibiotics.53.879

Y. J. Seo, G. H. Kim, H. J. Kwak, J. S. Nam, H. J. Lee et al., Validation of a HeLa <i>Mx2</i>/Luc Reporter Cell Line for the Quantification of Human Type I Interferons, Pharmacology, vol.84, issue.3, pp.135-144, 2009.
DOI : 10.1159/000235158

P. Szymá-nski, M. Markowicz, and E. Mikiciuk-olasik, Adaptation of high-throughput screening in drug discovery?toxicological screening tests, 2012.

V. A. Zapol-'skii, J. C. Namyslo, A. E. Adam, and D. Kaufmann, Chemistry of polyhalogenated nitrobutadienes: 1: a new synthesis of perfunctionalized 3-amino-4-nitrothiophenes, Heterocycles, vol.63, pp.1281-1298, 2004.

V. A. Zapol-'skii, J. C. Namyslo, G. Sergeev, M. Brönstrup, M. Gjikaj et al., Reinvestigation of the nitration of trichloroethene?subsequent reactions of the products and evaluation of their antimicrobial and antifungal activity, EJOC, vol.35, pp.7763-7774, 2015.

V. A. Zapol-'skii, J. C. Namyslo, A. De-meijere, and D. Kaufmann, Chemistry of polyhalogenated nitrobutadienes, 10: Synthesis of highly functionalized heterocycles with a rigid 6-amino-3-azabicyclo [3.1.0] hexane moiety, Beilstein. J. Org. Chem, vol.8, pp.621-628, 2012.

J. Zhang, T. Chung, and K. Oldenburg, A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays, Journal of Biomolecular Screening, vol.4, issue.2, pp.67-73, 1999.
DOI : 10.1177/108705719900400206