Skip to Main content Skip to Navigation
Journal articles

Astrocyte Dysfunction in Developmental Neurometabolic Diseases.

Silvia Olivera-Bravo 1 Eugenia Isasi 1 Anabel Fernández 2 Gabriela Casanova 3 Juan Carlos Rosillo 4 Luigi Barbeito 5
1 Cellular and Molecular Neurobiology Department [Montevideo]
2 IIBCE - Instituto de Investigaciones Biológicas Clemente Estable [Montevideo]
3 School of Sciences [Montevideo]
4 Comparative Neuroanatomy Associated Unit
5 Institut Pasteur de Montevideo
Abstract : Astrocytes play crucial roles in maintaining brain homeostasis and in orchestrating neural development, all through tightly coordinated steps that cooperate to maintain the balance needed for normal development. Here, we review the alterations in astrocyte functions that contribute to a variety of developmental neurometabolic disorders and provide additional data on the predominant role of astrocyte dysfunction in the neurometabolic neurodegenerative disease glutaric acidemia type I. Finally, we describe some of the therapeutical approaches directed to neurometabolic diseases and discuss if astrocytes can be possible therapeutic targets for treating these disorders.
Keywords : Neurodegeneration Myelin damage Astrocyte dysfunction Astrocytes Neurodevelopmental diseases
Document type :
Journal articles
Complete list of metadata
https://hal-riip.archives-ouvertes.fr/pasteur-01499023
Contributor : Mariella Botta <>
Submitted on : Thursday, March 30, 2017 - 8:08:28 PM
Last modification on : Monday, March 4, 2019 - 10:50:10 AM

Identifiers

Collections

RIIP | RIIP_MONTEVIDEO

Citation

Silvia Olivera-Bravo, Eugenia Isasi, Anabel Fernández, Gabriela Casanova, Juan Carlos Rosillo, et al.. Astrocyte Dysfunction in Developmental Neurometabolic Diseases.. Advances in Experimental Medicine and Biology, Kluwer, 2016, pp.227-243. ⟨10.1007/978-3-319-40764-7_11⟩. ⟨pasteur-01499023⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

92