Astrocyte Dysfunction in Developmental Neurometabolic Diseases.

Abstract : Astrocytes play crucial roles in maintaining brain homeostasis and in orchestrating neural development, all through tightly coordinated steps that cooperate to maintain the balance needed for normal development. Here, we review the alterations in astrocyte functions that contribute to a variety of developmental neurometabolic disorders and provide additional data on the predominant role of astrocyte dysfunction in the neurometabolic neurodegenerative disease glutaric acidemia type I. Finally, we describe some of the therapeutical approaches directed to neurometabolic diseases and discuss if astrocytes can be possible therapeutic targets for treating these disorders.
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Advances in Experimental Medicine and Biology, Kluwer, 2016, pp.227-243. 〈10.1007/978-3-319-40764-7_11〉
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Soumis le : jeudi 30 mars 2017 - 20:08:28
Dernière modification le : jeudi 20 septembre 2018 - 13:56:06

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Silvia Olivera-Bravo, Eugenia Isasi, Anabel Fernández, Gabriela Casanova, Juan Carlos Rosillo, et al.. Astrocyte Dysfunction in Developmental Neurometabolic Diseases.. Advances in Experimental Medicine and Biology, Kluwer, 2016, pp.227-243. 〈10.1007/978-3-319-40764-7_11〉. 〈pasteur-01499023〉

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