F. Costa, J. Hagan, and J. Calcagno, Global Morbidity and Mortality of Leptospirosis: A Systematic 367

A. Ko, C. Goarant, and M. Picardeau, Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen, Nature Reviews Microbiology, vol.27, issue.10, pp.736-783, 2009.
DOI : 10.1038/nrmicro2208
URL : https://hal.archives-ouvertes.fr/pasteur-00450871

D. Haake and P. Levett, Leptospirosis in humans. Current topics in microbiology and immunology 371 2015, pp.65-97
DOI : 10.1007/978-3-662-45059-8_5
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442676

M. Tajiki, A. Nakama, and R. Salomão, The Ratio Of Plasma Levels Of Il-10/Tnf-Alpha And Its 373

M. Mikulski, P. Boisier, and F. Lacassin, Severity markers in severe leptospirosis: a cohort study, European Journal of Clinical Microbiology & Infectious Diseases, vol.8, issue.3, p.376
DOI : 10.1007/s10096-014-2275-8
URL : https://hal.archives-ouvertes.fr/hal-01163060

E. Reis, J. Hagan, and G. Ribeiro, Cytokine response signatures in disease progression and 379 development of severe clinical outcomes for leptospirosis, PLoS neglected tropical diseases, vol.380, issue.7, pp.2457-381, 2013.

I. Kyriakidis, P. Samara, and A. Papa, Serum TNF-alpha, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's 382 syndrome, Cytokine, 2011.
DOI : 10.1016/j.cyto.2011.01.014

C. Chirathaworn, Y. Supputtamongkol, S. Lertmaharit, and Y. Poovorawan, Cytokine levels as biomarkers for leptospirosis patients, Cytokine, vol.85, pp.80-82, 2016.
DOI : 10.1016/j.cyto.2016.06.007

F. Vernel-pauillac and C. Goarant, Differential Cytokine Gene Expression According to Outcome in a Hamster Model of Leptospirosis, PLoS Neglected Tropical Diseases, vol.11, issue.1, pp.582-387, 2010.
DOI : 10.1371/journal.pntd.0000582.t002
URL : https://hal.archives-ouvertes.fr/pasteur-00449053

M. Matsui, V. Rouleau, L. Bruyere-ostells, and C. Goarant, Gene expression profiles of immune mediators 388

B. Adler and A. De-la-pena-moctezuma, Leptospira and leptospirosis, Veterinary microbiology, vol.391, issue.140, pp.287-96, 2010.

. Caledonia, The American journal of tropical medicine and hygiene, pp.982-987, 2015.

T. Arai, K. Hiromatsu, and H. Nishimura, Effects of in vivo administration of anti-IL-10 monoclonal 396 antibody on the host defence mechanism against murine Salmonella infection, Immunology, vol.397, issue.85, pp.381-389, 1995.

F. Merien, D. Portnoi, P. Bourhy, F. Charavay, A. Berlioz-arthaud et al., A rapid and 399 quantitative method for the detection of Leptospira species in human leptospirosis. FEMS microbiology 400 letters, pp.139-186, 2005.

. Leptospira-spp, through TaqMan polymerase chain reaction targeting the LipL32 gene. Diagnostic 403 microbiology and infectious disease, pp.247-55, 2009.

D. Chong and S. Sriskandan, Pro-Inflammatory Mechanisms in Sepsis, Contributions to microbiology 405, vol.17, pp.86-107, 2011.
DOI : 10.1159/000324022

S. Tubiana, M. Mikulski, and J. Becam, Risk Factors and Predictors of Severe Leptospirosis in New 410

S. Gregori, K. Goudy, and M. Roncarolo, The cellular and molecular mechanisms of immuno- 412 suppression by human type 1 regulatory T cells, Frontiers in immunology, vol.3, pp.30-413, 2012.

K. Taga and G. Tosato, IL-10 inhibits human T cell proliferation and IL-2 production, J Immunol, vol.414, issue.148, pp.1143-1151, 1992.

F. Sonderegger, Y. Ma, and H. Maylor-hagan, Localized production of IL-10 suppresses early 416

D. Athanazio, C. Santos, A. Santos, F. Mcbride, and M. Reis, Experimental infection in tumor 421

V. Petrilli, C. Dostert, D. Muruve, and J. Tschopp, The inflammasome, Current Biology, vol.15, issue.15, pp.615-637, 2007.
DOI : 10.1016/j.cub.2005.07.049

S. Lacroix-lamande, M. Andon, and E. Michel, Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome, The Journal of Immunology, vol.188, issue.6, pp.2805-2819, 2012.
DOI : 10.4049/jimmunol.1101987

J. Brown, J. Zachary, C. Teuscher, J. Weis, and R. Wooten, Dual role of interleukin-10 in murine 431

F. Merien, P. Amouriaux, P. Perolat, and G. Baranton, Saint Girons I. Polymerase chain reaction for 434 detection of Leptospira spp. in clinical samples, Journal of clinical microbiology, vol.30, pp.2219-2243, 1992.