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Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

Résumé : IKKε is an oncogenic kinase that was found amplified and overexpressed in a substantial percentage of human breast cancer cell lines and primary tumors using genomic and gene expression analyses. Molecular studies have provided the rational for a key implication of IKKε in breast cancer cells proliferation and invasiveness through the phosphorylation of several substrates.
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Submitted on : Tuesday, June 6, 2017 - 3:48:14 PM
Last modification on : Monday, July 20, 2020 - 12:34:51 PM

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Virginie Williams, Andrée-Anne Grosset, Natalia Zamorano Cuervo, yves St-Pierre, Marie-Pierre Sylvestre, et al.. Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.. BMC Cancer, BioMed Central, 2017, 17 (1), pp.356. ⟨10.1186/s12885-017-3321-6⟩. ⟨pasteur-01533564⟩

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