Cancer statistics, 2016, CA: A Cancer Journal for Clinicians, vol.61, issue.suppl 3, pp.7-30, 2016. ,
DOI : 10.3322/caac.20134
Molecular characterization and targeted therapeutic approaches in breast cancer, Breast Cancer Research, vol.25, issue.Suppl 2, p.60, 2015. ,
DOI : 10.1093/annonc/mdu112
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407294
Challenges in the stratification of breast tumors for tailored therapies, Bull Cancer, vol.93, issue.8, pp.81-90, 2006. ,
The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000. ,
DOI : 10.1016/S0092-8674(00)81683-9
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to I??B kinases, International Immunology, vol.11, issue.8, pp.1357-62, 1999. ,
DOI : 10.1093/intimm/11.8.1357
IKK?? Is Part of a Novel PMA-Inducible I??B Kinase Complex, Molecular Cell, vol.5, issue.3, pp.513-535, 2000. ,
DOI : 10.1016/S1097-2765(00)80445-1
IKK-i/IKK?? Controls Constitutive, Cancer Cell-associated NF-??B Activity via Regulation of Ser-536 p65/RelA Phosphorylation, Journal of Biological Chemistry, vol.19, issue.37, pp.26976-84, 2006. ,
DOI : 10.1074/jbc.C400442200
Inducible Phosphorylation of NF-??B p65 at Serine 468 by T Cell Costimulation Is Mediated by IKK??, Journal of Biological Chemistry, vol.269, issue.10, pp.6175-83, 2006. ,
DOI : 10.1016/S1097-2765(02)00477-X
Nuclear Accumulation of cRel following C-Terminal phosphorylation by TBK1/IKK??, The Journal of Immunology, vol.177, issue.4, pp.2527-2562, 2006. ,
DOI : 10.4049/jimmunol.177.4.2527
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway, Science, vol.300, issue.5622, pp.1148-51, 2003. ,
DOI : 10.1126/science.1081315
IKK?? and TBK1 are essential components of the IRF3 signaling pathway, Nature Immunology, vol.4, issue.5, pp.491-497, 2003. ,
DOI : 10.1038/ni921
Multiple Functions of the IKK-Related Kinase IKK?? in Interferon-Mediated Antiviral Immunity, Science, vol.17, issue.6, pp.1274-1282, 2007. ,
DOI : 10.1016/j.molcel.2005.02.021
Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene, Cell, vol.129, issue.6, pp.1065-79, 2007. ,
DOI : 10.1016/j.cell.2007.03.052
URL : http://doi.org/10.1016/j.cell.2007.03.052
Inducible I??B Kinase/I??B Kinase ?? Expression Is Induced by CK2 and Promotes Aberrant Nuclear Factor-??B Activation in Breast Cancer Cells, Cancer Research, vol.65, issue.24, pp.11375-83, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-1602
Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKK?? Promotes Cell Transformation, Molecular Cell, vol.34, issue.4, pp.461-72, 2009. ,
DOI : 10.1016/j.molcel.2009.04.031
I??B Kinase ?? Phosphorylates TRAF2 To Promote Mammary Epithelial Cell Transformation, Molecular and Cellular Biology, vol.32, issue.23, pp.4756-68, 2012. ,
DOI : 10.1128/MCB.00468-12
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497603
IKBKE Phosphorylation and Inhibition of FOXO3a: A Mechanism of IKBKE Oncogenic Function, PLoS ONE, vol.42, issue.5, p.63636, 2013. ,
DOI : 10.1371/journal.pone.0063636.s003
Silencing of the IKK?? gene by siRNA inhibits invasiveness and growth of breast cancer cells, Breast Cancer Research, vol.285, issue.5, p.74, 2010. ,
DOI : 10.1074/jbc.M109.078212
IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation, Journal of Biological Chemistry, vol.166, issue.43, pp.37389-98, 2011. ,
DOI : 10.2174/156802610790980602
Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth, Journal of Clinical Investigation, vol.124, issue.12, pp.5411-5434, 2014. ,
DOI : 10.1172/JCI75661DS1
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348940
IKK?? Phosphorylation of Estrogen Receptor ?? Ser-167 and Contribution to Tamoxifen Resistance in Breast Cancer, Journal of Biological Chemistry, vol.61, issue.6, pp.3676-84, 2010. ,
DOI : 10.1074/jbc.274.36.25245
Overexpression of Galectin-7, A Myoepithelial Cell Marker, Enhances Spontaneous Metastasis of Breast Cancer Cells, The American Journal of Pathology, vol.176, issue.6, pp.3023-3054, 2010. ,
DOI : 10.2353/ajpath.2010.090876
URL : https://hal.archives-ouvertes.fr/pasteur-00819591
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets, Oncotarget, vol.7, issue.14, pp.18183-203, 2016. ,
DOI : 10.18632/oncotarget.7784
URL : https://hal.archives-ouvertes.fr/pasteur-01351190
Redox-modulating agents target NOX2-dependent IKK?? oncogenic kinase expression and proliferation in human breast cancer cell lines, Redox Biology, vol.6, pp.9-18, 2015. ,
DOI : 10.1016/j.redox.2015.06.010
I??B-Kinase-?? (IKK??/IKKi/I??BK??) expression and localization in prostate cancer tissues, The Prostate, vol.65, issue.24, pp.1131-1139, 2011. ,
DOI : 10.1158/0008-5472.CAN-05-1602
IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis, Proceedings of the National Academy of Sciences, vol.7, issue.11, pp.11139-11183, 2013. ,
DOI : 10.1371/journal.ppat.1002336
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703966
Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma, Cancer Res, vol.48, issue.1, pp.161-165, 1988. ,
Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors, British Journal of Cancer, vol.10, issue.10, pp.1922-1928, 2005. ,
DOI : 10.1126/science.1099314
Epidermal growth factor receptor (EGFR) signaling in cancer, Gene, vol.366, issue.1, pp.2-16, 2006. ,
DOI : 10.1016/j.gene.2005.10.018
Structure and expression of c-erbB-2 and EGF receptor genes in inflammatory and non-inflammatory breast cancer: Prognostic significance, International Journal of Cancer, vol.49, issue.2 ,
DOI : 10.1128/MCB.7.5.2019
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer, BMC Cancer, vol.50, issue.4, p.134, 2007. ,
DOI : 10.1111/j.1365-2559.2007.02638.x
Emerging EGFR antagonists for breast cancer, Expert Opinion on Emerging Drugs, vol.94, issue.6, pp.165-81, 2014. ,
DOI : 10.1007/s10549-012-1997-5
Role of epidermal growth factor receptor in breast cancer, Breast Cancer Research and Treatment, vol.7, issue.2, pp.331-376, 2012. ,
DOI : 10.3816/CBC.2006.n.040
IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non-Small Cell Lung Cancer with Activating Mutations of EGFR, Cancer Research, vol.76, issue.15, pp.4418-4447, 2016. ,
DOI : 10.1158/0008-5472.CAN-16-0069
Deregulation of IKBKE Is Associated with Tumor Progression, Poor Prognosis, and Cisplatin Resistance in Ovarian Cancer, The American Journal of Pathology, vol.175, issue.1, pp.324-357, 2009. ,
DOI : 10.2353/ajpath.2009.080767
IKKepsilon and TBK1 expression in gastric cancer, Oncotarget, 2016. ,
DOI : 10.18632/oncotarget.9069
The Non-Canonical IκB Kinases IKKε and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs, Current Molecular Medicine, vol.13, issue.7, pp.1089-97, 2013. ,
DOI : 10.2174/1566524011313070004
La kinase IKK??, m??decine/sciences, vol.27, issue.6-7, pp.619-644, 2011. ,
DOI : 10.1051/medsci/2011276014
Novel cross-talk within the IKK family controls innate immunity, Biochemical Journal, vol.5, issue.1, pp.93-104, 2011. ,
DOI : 10.1128/MCB.01101-07
URL : https://hal.archives-ouvertes.fr/hal-00560693
Synthesis and structure???activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKK?? kinases, Bioorganic & Medicinal Chemistry Letters, vol.22, issue.23, pp.7169-73, 2012. ,
DOI : 10.1016/j.bmcl.2012.09.063
shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer, Cancer Research, vol.74, issue.7, pp.2119-2149, 2014. ,
DOI : 10.1158/0008-5472.CAN-13-2138
Selective TBK1/IKKi dual inhibitors with anticancer potency, International Journal of Cancer, vol.228, issue.8, pp.1972-80, 2014. ,
DOI : 10.1002/jcp.24115
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947486
Mechanism of Action of an Antiallergic Agent, Amlexanox (AA-673), in Inhibiting Histamine Release from Mast Cells, International Archives of Allergy and Immunology, vol.82, issue.1, pp.66-71, 1987. ,
DOI : 10.1159/000234292
An inhibitor of the protein kinases TBK1 and IKK-?? improves obesity-related metabolic dysfunctions in mice, Nature Medicine, vol.2005, issue.3, pp.313-334, 2013. ,
DOI : 10.1126/stke.2682005pe4