Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection.

Abstract : Type I interferons (IFN-I) have long been heralded as key contributors to effective antiviral responses. More widely understood in the context of acute viral infection, the role of this pleiotropic cytokine has been characterized as triggering antiviral states in cells and potentiating adaptive immune responses. Upon induction in the innate immune response, IFN-I triggers the expression of interferon-stimulated genes (ISGs), which upregulate the effector function of immune cells (e.g., dendritic cells, B cells, and T cells) toward successful resolution of infections. However, emerging lines of evidence reveal that viral persistence in the course of chronic infections could be driven by deleterious immunomodulatory effects upon sustained IFN-I expression. In this setting, elevation of IFN-I and ISGs is directly correlated to viral persistence and elevated viral loads. It is important to note that the correlation among IFN-I expression, ISGs, and viral persistence may be a cause or effect of chronic infection and this is an important distinction to make toward establishing the dichotomous nature of IFN-I responses. The aim of this mini review is to (i) summarize the interaction between IFN-I and downstream effector responses and therefore (ii) delineate the function of this cytokine on positive and negative immunoregulation in chronic infection. This is a significant consideration given the current therapeutic administration of IFN-I in chronic viral infections whose therapeutic significance is projected to continue despite emergence of increasingly efficacious antiviral regimens. Furthermore, elucidation of the interplay between virus and the antiviral response in the context of IFN-I will elucidate avenues toward more effective therapeutic and prophylactic measures against chronic viral infections.
Type de document :
Article dans une revue
Frontiers in Immunology, Frontiers, 2016, 7, pp.609. 〈10.3389/fimmu.2016.00609〉
Liste complète des métadonnées

Littérature citée [80 références]  Voir  Masquer  Télécharger

https://hal-riip.archives-ouvertes.fr/pasteur-01534446
Contributeur : Michel Courcelles <>
Soumis le : mercredi 7 juin 2017 - 15:39:24
Dernière modification le : jeudi 6 juillet 2017 - 01:03:09
Document(s) archivé(s) le : vendredi 8 septembre 2017 - 12:54:39

Fichier

fimmu-07-00609.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Armstrong Murira, Alain Lamarre. Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection.. Frontiers in Immunology, Frontiers, 2016, 7, pp.609. 〈10.3389/fimmu.2016.00609〉. 〈pasteur-01534446〉

Partager

Métriques

Consultations de la notice

10

Téléchargements de fichiers

21