1. , B. D. , J. =. , H. Dd, and J. =. , C NMR (100 MHz, CD 3 OD) ?: 168.34 (s, C-7 VI ), 167.03 (s, C-7 I ), 12.0, 4.9 Hz, pp.547151-146

C. Nmr, 42 (s, C-7 I ), 146.56 (s, C-4 I ), 146.39 (s, C-4 III ), 146.36 (s, C-4 II ), 140.68 (s, C-3,5 I ), 140.20 (s, C-3,5 II ), 139.99 (s, C-3,5 III ), 121.09 (s, C- 1 III )51 (s, C-1 II )00 (s, C-1 I ), 110.56 (d, C- 2,6 I ), 110.43 (d, C-2,6 III ) 1,2,6-Tri-O-galloyl-?-D-glucopyranose (3): Brown amorphous solid, H NMR (400 MHz, CD 3 OD) ?: 7.11 (2H, s, H-2,6 VI ), 7.05 (2H1H, dd, J = 12.1, 4.6 Hz, H-6b), pp.167-834535, 1979.

D. Hz1h, J. =. Dd, and J. =. , 13 C NMR (100 MHz, CD 3 OD) ?: 168.19 (s, C-7 VI )74 (s, C-7 III ), 167.20 (s, C-7 II ), 166.34 (s, C-7 I ), 146.54 (s, C-4 VI ), 146.54 (s, C-4 I ), 146.38 (s, C-4 III ), 146.35 (s, C-4 II ), 140.75 (s, C-3,5 I ), 140.24 (s, C-3,5 II ), 140.03 (s, C-3,5 III ), 140.00 (s, C-3,5 VI ), 121.23 (s, C-1 VI ), 120.98 (s, C-1 III ), 120.41 (s, C-1 II ), 119.84 (s, C-1 I ), III ) II ), pp.4-7

B. D. Hz1h and J. =. , 39 (1H, m, H-6b); 13 C NMR (100 MHz, CD 3 OD) ?: 167, 167.03 (C-7 II ), 166.93 (C-7 IV ) IV ), 146.39 (C-3 II ), 146.30 (C-3 III ), pp.4-52

I. Tellimagrandin, T. , and J. =. , Brown amorphous solid MeOH); 1 H NMR (400 MHz, CD 3 OD) ?: ?-anomer (60%): 7.01 (2H, s, H-2,6 II ), 6.92 (2H, s, H-2,6 III ), 6.60 (1H, s, H-2 VI ), 6.49 (1H, s, H-2 IV ), 5.83 (1H, t, J = 10, 1H, dd, J = 12.7, 6.6 Hz, H-6), 5.12 (1H, t, J = 9.9 Hz1H, s, H-2 IV ), pp.496-502, 1932.

D. Hz1h, J. =. 121h, J. =. Dd, T. , J. =. Dd et al., 90 (1H, d, J = 13.0 Hz, H-6); 13 C NMR (100 MHz, CD 3 OD) ?: ? anomer: 169.78 (s, C-7 VI ), 169.32 (s, C-7 IV ), 167.94 (s, C-7 III ), 167.48 (s, C-7 II ), 146.41 (s, C-4 II ), 146.22 (s, C-4 III ), 145.94 (s, C-4 IV ), 145.87 (s, C-4 VI ), 144.82 (2×, s, C-5 IV and C-5 VI ), 140.16 (s, C-3,5 II ), 139.93 (s, C-3,5 III ), 137.62 (2×, s, C-3 IV and C-3 VI ), 126.36 (s, C-1 IV ), 125.96 (s, C-1 VI ) (s, C-1 III ) (s, C-1 II ), VI ), pp.35-40

I. Tellimagrandin, Brown amorphous solid MeOH); 1 H NMR (400 MHz, CD 3 OD) ?: 7.05 (2H, s, H-2,6 I ), III ), 6.61 (1H, s, H-2 VI ), 6.48 (1H, s, H-2 IV )1H, d, J = 8.3 Hz, p.955439

T. Hz1h, J. =1h, and J. =. Dd, 13 C NMR (100 MHz, CD 3 OD) ?: 169.59 (s, C-7 VI ), 169.24 (s, C-7 IV )57 (s, C-7 III )92 (s, C-7 II ), 166.19 (s, C-7 I ), 146.62 (s, C-4 I ), 146.43 (s, C-4 II ), 146.27 (s, C-4 III )86 (s, C-4 IV ), 145.82 (s, C-4 VI ), 145.17 (s, C-5 IV ), 145.15 (s, C- 5 VI ), 140.82 (s, C-3,5 I ), 140.33 (s, C-3,5 II ), 140.11 (s, C- 3,5 III ), 137.80 (s, C-3 IV ), 137.78 (s, C-3 VI ), 126.24 (s, C-1 IV ), 126.24 (s, C-1 VI ), 120.45 (s, C-1 III ), 120.32 (s, C-1 II ) (s, C-1 I ), VI ), 116.69 (d, C-6 IV ) II ), 108.59 (d, C- 2 VI ), 108.21 (d, C-2 IV ), pp.4-43

E. Gallate, Brown amorphous solid, H NMR (400 MHz, CD 3 OD) ?: 7.05 (2H, s, pp.4-27

H. Hz, T. , and J. =. , 13 C NMR (100 MHz, CD 3 OD) ?: 168.58 (s, C-7), 146.50 (s, C-3,5), 139.71 (s, C-4), 121.77 (s, C-1) Caffeic acid (9): White amorphous solid, H NMR (400 MHz, CD 3 OD) ?: 7.59 (1H, d, J = 15.9 Hz, pp.0-61

D. Hz1h, J. =1h, D. , and J. =. , 9 Hz, H-8); 13 C NMR (100 MHz, CD 3 OD) ?: 169.05 (s, C-9), p.77306576522088

. Astragalin, Yellow amorphous solid, MeOH, vol.10

H. Hz and J. =. Dd, H-5?); 13 C NMR (100 MHz, CD 3 OD) ?: 179.53 (s, C-4), 166.21 (s, C-7), 163.11 (s, C-5) Isoquercetin Yellow amorphous solid, ), 3.20 (1H, ddd, J = 9.7, 5.5, 2.3 Hz 132.31 (d, C-2?,6?), pp.69-72

D. Reinutrin1h, J. =1h, T. , and J. =. , Brown amorphous solid; 1 H NMR (400 MHz, CD 3 OD) ?: 7, 1H, m, H-6?)1H, br s, p.8539785039, 1920.

D. Hz1h, 13 C NMR (100 MHz, CD 3 OD) ?: 166, 163.1 (C-5), 159.8 (C-2) 123.1 (C-1?), pp.75-78

H. Hz, D. , J. =1h, D. , J. =. et al., 50 (2H, m, H-5?); 13 C NMR (100 MHz, CD 3 OD) ?: 180.02 (s, C (s, C-3), 123.13 (s, C-1?), ), 3.92 (1H, dd, J = 5.2, 2.9 Hz, H-3?), 3.86 (1H, m 159.38 (s, C-2), 158.62 (s, C-9), 149.90 (s, C-4?), pp.9140-9146

1. , D. , J. =. , D. , J. =1h et al., 86 (1H, br d, J = 12.2 Hz, 12.2, 5.7 Hz, H-6?b), 3.43 (1H, m, H- 5?), 3.39 (1H, m, pp.5938-5942

. Hz, 10 (3H, s, H-12), 1.01 (3H, s, H-11); 13 C NMR (100 MHz, CD 3 OD) ?: 202, p.17

K. Looker, A. Magaret, M. May, K. Turner, P. Vickerman et al., Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012, PLOS ONE, vol.32, issue.Suppl 1, 2015.
DOI : 10.1371/journal.pone.0140765.s008

C. Stock, F. Guillén-grima, D. Mendoza, J. Marin-fernandez, B. Aguinaga-ontoso et al., Risk factors of herpes simplex type 1 (HSV-1) infection and lifestyle factors associated with HSV-1 manifestations, European Journal of Epidemiology, vol.17, issue.9, pp.885-90, 2001.
DOI : 10.1023/A:1015652713971

R. Whitley, S. Tyring, L. Hollier, and S. Brunton, Emerging issues in the management of herpes simplex virus infections, Johns Hopkins Advanced Studies in Medicine, vol.6, pp.1092-103, 2006.

B. Dreno, J. Malkin, and P. Saiag, Understanding recurrent herpes labialis management and impact on patients' quality of life: The HERPESCOPE study, Eur J Dermatol, vol.23, pp.491-500, 2013.

R. Levitz, Herpes simplex encephalitis: A review, Heart & Lung: The Journal of Acute and Critical Care, vol.27, issue.3, pp.209-221, 1998.
DOI : 10.1016/S0147-9563(98)90009-7

I. Steiner and F. Benninger, Update on Herpes Virus Infections of the Nervous System, Current Neurology and Neuroscience Reports, vol.366, issue.12, p.414, 2013.
DOI : 10.1056/NEJMoa1103151

S. James and M. Prichard, Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance, Current Opinion in Virology, vol.8, pp.54-61, 2014.
DOI : 10.1016/j.coviro.2014.06.003

A. Cunningham, P. Griffiths, P. Leone, A. Mindel, R. Patel et al., Current management and recommendations for access to antiviral therapy of herpes labialis, Journal of Clinical Virology, vol.53, issue.1, pp.6-11, 2012.
DOI : 10.1016/j.jcv.2011.08.003

E. Orion, H. Matz, and R. Wolf, The life-threatening complications of dermatologic therapies, Clinics in Dermatology, vol.23, issue.2, pp.182-92, 2005.
DOI : 10.1016/j.clindermatol.2004.06.013

D. Newman and G. Cragg, Natural Products as Sources of New Drugs from 1981 to 2014, Journal of Natural Products, vol.79, issue.3, pp.629-61, 2016.
DOI : 10.1021/acs.jnatprod.5b01055

S. Hassan, R. Masar?íková, and K. Berchová, Bioactive natural products with anti-herpes simplex virus properties, Journal of Pharmacy and Pharmacology, vol.57, issue.11 Suppl., pp.1325-1361, 2015.
DOI : 10.1021/np50103a027

A. Kolb, C. Ané, and C. Brandt, Using HSV-1 Genome Phylogenetics to Track Past Human Migrations, PLoS ONE, vol.3, issue.10, p.76267, 2013.
DOI : 10.1371/journal.pone.0076267.s002

URL : http://doi.org/10.1371/journal.pone.0076267

D. Moerman, Native american ethnobotany, 1998.

H. Wagner and S. Bladt, Plant Drug Analysis. A Thin Layer Chromatography Atlas, 1996.

R. Owen, R. Haubner, W. Hull, G. Erben, B. Spiegelhalder et al., Isolation and structure elucidation of the major individual polyphenols in carob fibre, Food and Chemical Toxicology, vol.41, issue.12, pp.1727-1765, 2003.
DOI : 10.1016/S0278-6915(03)00200-X

K. Wang, C. Yang, and Y. Zhang, Phenolic antioxidants from Chinese toon (fresh young leaves and shoots of Toona sinensis), Food Chemistry, vol.101, issue.1, pp.365-71, 2006.
DOI : 10.1016/j.foodchem.2006.01.044

K. Cheng, R. Yang, S. Tsou, C. Lo, C. Ho et al., Analysis of antioxidant activity and antioxidant constituents of Chinese toon, Journal of Functional Foods, vol.1, issue.3, pp.253-262, 2009.
DOI : 10.1016/j.jff.2009.01.013

J. Cho, M. Sohn, J. Lee, and W. Kim, Isolation and identification of pentagalloylglucose with broad-spectrum antibacterial activity from Rhus trichocarpa Miquel, Food Chemistry, vol.123, issue.2, pp.501-507, 2010.
DOI : 10.1016/j.foodchem.2010.04.072

Y. Chen, J. Wang, Y. Ou, H. Chen, S. Xiao et al., Cellular antioxidant activities of polyphenols isolated from Eucalyptus leaves (Eucalyptus grandis??Eucalyptus urophylla GL9), Journal of Functional Foods, vol.7, pp.737-782, 2014.
DOI : 10.1016/j.jff.2013.12.003

S. Takaoka, N. Takaoka, Y. Minoshima, J. Huang, M. Kubo et al., Isolation, synthesis, and neurite outgrowth-promoting activity of illicinin A from the flowers of Illicium anisatum, Tetrahedron, vol.65, issue.40, pp.8354-61, 2009.
DOI : 10.1016/j.tet.2009.08.015

C. Kelley, R. Harruff, and M. Carmack, Polyphenolic acids of Lithospermum ruderale. II. Carbon-13 nuclear magnetic resonance of lithospermic and rosmarinic acids, The Journal of Organic Chemistry, vol.41, issue.3, pp.449-55, 1976.
DOI : 10.1021/jo00865a007

J. Han, M. Bang, O. Chun, D. Kim, C. Lee et al., Flavonol glycosides from the aerial parts ofAceriphyllum rossii and their antioxidant activities, Archives of Pharmacal Research, vol.29, issue.3, pp.390-395, 2004.
DOI : 10.1248/cpb.40.2080

S. Scharbert, N. Holzmann, and T. Hofmann, Identification of the Astringent Taste Compounds in Black Tea Infusions by Combining Instrumental Analysis and Human Bioresponse, Journal of Agricultural and Food Chemistry, vol.52, issue.11, pp.3498-508, 2004.
DOI : 10.1021/jf049802u

A. Hyun, R. Ae, Y. Hae, and J. Sc, In vitro antioxidant activity of some selected Prunus species in Korea, Arch Pharmacal Res, vol.25, pp.865-72, 2002.

S. Kadota, Y. Takamori, N. Khin, T. Kikuchi, K. Tanaka et al., Constituents of the leaves of Woodfordia fruticosa Kurz. I. Isolation, structure, and proton and carbon-13 nuclear magnetic resonance signal assignments of woodfruticosin (woodfordin C), an inhibitor of deoxyribonucleic acid topoisomerase II., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.38, issue.10, pp.2687-97, 1990.
DOI : 10.1248/cpb.38.2687

K. Hyoung, E. Woo, and H. Park, A novel lignan and flavonoids from Polygonum aviculare, J Nat Prod, vol.57, pp.581-587, 1994.

H. Lin, S. Tsai, and S. Lee, Flavonoid Glycosides from the Leaves of Machilus philippinensis, Journal of the Chinese Chemical Society, vol.93, issue.4, pp.555-62, 2011.
DOI : 10.1002/hlca.200900264

D. Abrosca, B. Dellagreca, M. Fiorentino, A. Monaco, P. Previtera et al., Potential allelochemicals from Sambucus nigra, Phytochemistry, vol.58, issue.7, pp.1073-81, 2001.
DOI : 10.1016/S0031-9422(01)00401-0

K. Matsunami, H. Otsuka, and Y. Takeda, Structural Revisions of Blumenol C Glucoside and Byzantionoside B, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.58, issue.3, pp.438-479, 2010.
DOI : 10.1248/cpb.58.438

W. Russell, A Sensitive and Precise Plaque Assay for Herpes Virus, Nature, vol.82, issue.4845, pp.1028-1037, 1962.
DOI : 10.1016/0042-6822(62)90290-8

O. 'brien, J. Wilson, I. Orton, T. Pognan, and F. , Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity, European Journal of Biochemistry, vol.107, issue.17, pp.5421-5427, 2000.
DOI : 10.1016/0009-8981(80)90442-8

C. Koch, J. Reichling, J. Schneele, and P. Schnitzler, Inhibitory effect of essential oils against herpes simplex virus type 2, Phytomedicine, vol.15, issue.1-2, pp.71-79, 2008.
DOI : 10.1016/j.phymed.2007.09.003

F. Stermitz and R. Krull, Iridoid glycosides of Cornus canadensis, Biochemical Systematics and Ecology, vol.26, issue.8, pp.845-854, 1998.
DOI : 10.1016/S0305-1978(98)00050-7

P. Bermejo, M. Abad, A. Díaz, L. Fernández, D. Santos et al., Antiviral Activity of Seven Iridoids, Three Saikosaponins and One Phenylpropanoid Glycoside Extracted from Bupleurum rigidum and Scrophularia scorodonia, Planta Medica, vol.68, issue.2, pp.106-116, 2002.
DOI : 10.1055/s-2002-20238

J. Bain and K. Denford, The flavonoid glycosides ofCornus canadensis L. and its allies in Northwestern North America, Experientia, vol.55, issue.7, pp.863-867, 1979.
DOI : 10.1007/978-3-642-88458-0

M. Khan, A. Ather, K. Thompson, and R. Gambari, Extracts and molecules from medicinal plants against herpes simplex viruses, Antiviral Research, vol.67, issue.2, pp.107-126, 2005.
DOI : 10.1016/j.antiviral.2005.05.002

T. Kaul, M. Jr, E. Ogra, and P. , Antiviral effect of flavonoids on human viruses, Journal of Medical Virology, vol.57, issue.1, pp.71-80, 1985.
DOI : 10.1001/jama.1956.02970300027010

M. Takechi, Y. Tanaka, M. Takehara, G. Nonaka, and I. Nishioka, Structure and antiherpetic activity among the Tannins, Phytochemistry, vol.24, issue.10, pp.2245-50, 1985.
DOI : 10.1016/S0031-9422(00)83018-6

M. Kurokawa, T. Hozumi, P. Basnet, M. Nakano, S. Kadota et al., Purification and characterization of Eugeniin as an anti-herpes virus compound from Geum japonicum and Syzygium aromaticum, J Pharmacol Exp Ther, vol.284, pp.728-763, 1998.

Y. Pei, Z. Chen, H. Ju, M. Komatsu, Y. Ji et al., Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro, Biochemical and Biophysical Research Communications, vol.405, issue.2, pp.186-91, 2011.
DOI : 10.1016/j.bbrc.2011.01.006

Y. Pei, Y. Xiang, J. Chen, C. Lu, J. Hao et al., Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection, Antiviral Research, vol.89, issue.1, pp.98-108, 2011.
DOI : 10.1016/j.antiviral.2010.11.012

K. Fukuchi, H. Sakagami, T. Okuda, T. Hatano, S. Tanuma et al., Inhibition of herpes simplex virus infection by tannins and related compounds, Antiviral Research, vol.11, issue.5-6, pp.285-97, 1989.
DOI : 10.1016/0166-3542(89)90038-7

J. Legault, A. Pichette, I. Côté, and S. Lavoie, Université du Québec à Chicoutimi, assignee. Use of plant extracts against herpes simplex virus