Dechlorane Plus induces oxidative stress and decreases cyclooxygenase activity in the blue mussel.

Abstract : Dechlorane Plus (DP) is a chlorinated flame retardant used mainly in electrical wire and cable coating, computer connectors, and plastic roofing materials. Concentrations of DP (syn and anti isomers) are increasingly being reported in aquatic ecosystems worldwide. However, there is exceedingly little information on the exposure-related toxicity of DP in aquatic organisms, especially in bivalves. The objective of this study was to investigate the in vivo and in vitro effects of DP exposure on histopathology, lipid peroxidation (LPO) levels, cyclooxygenase (COX) activity, phagocytosis capacity and efficiency, and DNA strand breakage in the blue mussel (Mytilus edulis) following a 29days exposure (0.001, 0.01, 0.1 and 1.0μg DP/L). Blue mussels accumulated DP in muscle and digestive gland in a dose-dependent manner. LPO levels in gills were found to increase by 82% and 67% at the 0.01 and 1.0μg DP/L doses, respectively, while COX activity in gills decreased by 44% at the 1μg/L dose. No histopathological lesion was found in gonads following DP exposure. Moreover, no change in hemocyte DNA strand breakage, phagocytosis rate, and viability was observed following DP exposure. Present study showed that toxicity of DP may occur primarily via oxidative stress in the blue mussel and potentially other bivalves, and that gills represent the most responsive tissue to this exposure.
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Aquatic Toxicology, Elsevier, 2017, 188, pp.26-32. 〈10.1016/j.aquatox.2017.04.009〉
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Soumis le : jeudi 8 juin 2017 - 15:27:33
Dernière modification le : lundi 5 février 2018 - 15:22:10

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Pierre-Luc Gagné, Marlène Fortier, Marc Fraser, Lise Parent, Cathy Vaillancourt, et al.. Dechlorane Plus induces oxidative stress and decreases cyclooxygenase activity in the blue mussel.. Aquatic Toxicology, Elsevier, 2017, 188, pp.26-32. 〈10.1016/j.aquatox.2017.04.009〉. 〈pasteur-01534981〉

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