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Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection.

Abstract : Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively. Here, we show that, in addition to its effect on T cells, IFN-I drives impairment of specific antibody responses through interaction with B cells in the acute phase of lymphocytic choriomeningitis virus (LCMV) infection. This impairment was limited to the T cell-dependent B cell response and was associated with disruption of B cell follicles, development of hypergammaglobulinemia (HGG), and expansion of the T follicular helper cell population. Antigen-specific antibody responses were restored by ablation of IFN-I signaling through antibody-mediated IFN-I receptor blockade and B cell-specific IFN-I receptor knockout. Importantly, IFN-I receptor deficiency in B cells also accelerated the development of LCMV neutralizing antibodies and alleviated HGG. These results provide a potential therapeutic target toward efficient treatment measures that limit immunopathology in persistent viral infections.
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Submitted on : Thursday, June 8, 2017 - 7:56:28 PM
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Matthieu Daugan, Armstrong Murira, Barbara C Mindt, Amélie Germain, Esther Tarrab, et al.. Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection.. Frontiers in Immunology, 2016, 7, pp.564. ⟨10.3389/fimmu.2016.00564⟩. ⟨pasteur-01535181⟩



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