The ABCs of membrane transporters in health and disease (SLC series): Introduction, Molecular Aspects of Medicine, vol.34, issue.2-3, pp.95-107, 2013. ,
DOI : 10.1016/j.mam.2012.12.009
Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1, Journal of Biological Chemistry, vol.21, issue.36, pp.30485-30496, 2012. ,
DOI : 10.1152/ajpcell.00054.2010
Evolutionary analysis of Slc11 mechanism of proton-coupled metal-ion transmembrane import, AIMS Biophysics, vol.3, issue.2, pp.286-318, 2013. ,
DOI : 10.3934/biophy.2016.2.286
URL : https://hal.archives-ouvertes.fr/pasteur-01535408
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons, Nature Genetics, vol.47, issue.4, pp.427-437, 2016. ,
DOI : 10.1186/gb-2010-11-10-r106
URL : http://www.nature.com/ng/journal/v48/n4/pdf/ng.3526.pdf
Nramp1 phagocyte intracellular metal withdrawal defense, Microbes and Infection, vol.9, issue.14-15, pp.1662-1670, 2007. ,
DOI : 10.1016/j.micinf.2007.09.006
Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg, Cell, vol.73, issue.3, pp.469-485, 1993. ,
DOI : 10.1016/0092-8674(93)90135-D
Function and Mechanism of Action of Dictyostelium Nramp1 (Slc11a1) in Bacterial Infection, Traffic, vol.205, issue.1, pp.22-38, 2006. ,
DOI : 10.1091/mbc.7.2.261
Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport, Nature Structural & Molecular Biology, vol.93, issue.11, pp.990-996, 2014. ,
DOI : 10.1073/pnas.93.23.13362
Expansion of the APC superfamily of secondary carriers, Proteins: Structure, Function, and Bioinformatics, vol.193, issue.2-3, pp.2797-2811, 2014. ,
DOI : 10.1128/JB.01397-10
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters, Nature, vol.279, issue.7056, pp.215-223, 2005. ,
DOI : 10.1021/bi030161q
Structural Symmetry in Membrane Proteins, Annual Review of Biophysics, vol.44, issue.1, pp.311-337, 2015. ,
DOI : 10.1146/annurev-biophys-051013-023008
Nutritional Immunity: Homology Modeling of Nramp Metal Import, Adv Exp Med Biol, vol.946, pp.335-351, 2012. ,
DOI : 10.1007/978-1-4614-0106-3_19
Common Folds and Transport Mechanisms of Secondary Active Transporters, Annual Review of Biophysics, vol.42, issue.1, pp.51-72, 2013. ,
DOI : 10.1146/annurev-biophys-083012-130429
Molecular basis of substrate-induced permeation by an amino acid antiporter, Proceedings of the National Academy of Sciences, vol.459, issue.7245, pp.3935-3940, 2011. ,
DOI : 10.1038/nature08143
Unlocking the molecular secrets of sodium-coupled transporters, Nature, vol.30, issue.7245, pp.347-355, 2009. ,
DOI : 10.1038/nature08143
The structural basis of secondary active transport mechanisms, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1807, issue.2, pp.167-188, 2011. ,
DOI : 10.1016/j.bbabio.2010.10.014
The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport, Science, vol.46, issue.44, pp.810-814, 2008. ,
DOI : 10.1074/jbc.M308253200
Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter, Science, vol.50, issue.1, pp.709-713, 2008. ,
DOI : 10.1007/BF00872218
Molecular basis of transport and regulation in the Na+/betaine symporter BetP, Nature, vol.50, issue.7234, pp.47-52, 2009. ,
DOI : 10.1161/01.HYP.16.6.595
Structure and Mechanism of an Amino Acid Antiporter, Science, vol.211, issue.5052, pp.1565-1568, 2009. ,
DOI : 10.1038/211969a0
Structure and Mechanism of a Na+-Independent Amino Acid Transporter, Science, vol.61, issue.4, pp.1010-1014, 2009. ,
DOI : 10.1002/prot.20660
Structure of a prokaryotic virtual proton pump at 3.2????? resolution, Nature, vol.52, pp.1040-1043, 2009. ,
DOI : 10.1042/bj3360069
Mechanism of substrate recognition and transport by an amino acid antiporter, Nature, vol.31, issue.7282, pp.828-832, 2010. ,
DOI : 10.1099/00221287-146-8-1797
Crystal structure of the carnitine transporter and insights into the antiport mechanism, Nature Structural & Molecular Biology, vol.37, issue.4, pp.492-496, 2010. ,
DOI : 10.1128/jb.178.17.5071-5079.1996
Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1, Science, vol.24, issue.6, pp.470-473, 2010. ,
DOI : 10.1152/physiol.00030.2009
Structural basis of Na+-independent and cooperative substrate/product antiport in CaiT, Nature, vol.273, issue.7312, pp.233-236, 2010. ,
DOI : 10.1128/jb.177.16.4690-4695.1995
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states, Nature, vol.66, issue.7382, pp.469-474, 2012. ,
DOI : 10.1107/S0907444909042073
Structure and mechanism of a glutamate???GABA antiporter, Nature, vol.31, issue.7391, pp.632-636, 2012. ,
DOI : 10.1074/jbc.274.47.33244
Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP, Proceedings of the National Academy of Sciences, vol.106, issue.49, pp.3035-3044, 2012. ,
DOI : 10.1073/pnas.0908570106
Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling, Nature Communications, vol.14, p.4231, 2014. ,
DOI : 10.1016/0263-7855(96)00018-5
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters, Nature Structural & Molecular Biology, vol.98, issue.11, pp.1006-1012, 2014. ,
DOI : 10.1073/pnas.181342398
Predicting functional divergence in protein evolution by site-specific rate shifts, Trends in Biochemical Sciences, vol.27, issue.6, pp.315-321, 2002. ,
DOI : 10.1016/S0968-0004(02)02094-7
Using Evolutionary Rates to Investigate Protein Functional Divergence and Conservation. A case study of the carbonic anhydrases, Genetics, vol.164, pp.1261-1269, 2003. ,
DIVERGE: phylogeny-based analysis for functional-structural divergence of a protein family, Bioinformatics, vol.18, issue.3, pp.500-501, 2002. ,
DOI : 10.1093/bioinformatics/18.3.500
An Update of DIVERGE Software for Functional Divergence Analysis of Protein Family, Molecular Biology and Evolution, vol.30, issue.7, pp.1713-1719, 2013. ,
DOI : 10.1093/molbev/mst069
Causes of evolutionary rate variation among protein sites, Nature Reviews Genetics, vol.487, issue.2, pp.109-121, 2016. ,
DOI : 10.1093/molbev/msv167
Determinants of the rate of protein sequence evolution, Nature Reviews Genetics, vol.13, issue.7, pp.409-420, 2015. ,
DOI : 10.1093/molbev/mst065
The functional importance of co-evolving residues in proteins, Cellular and Molecular Life Sciences, vol.454, issue.7201, pp.673-682, 2014. ,
DOI : 10.1038/nature07063
Emerging methods in protein co-evolution, Nature Reviews Genetics, vol.485, issue.4, pp.249-261, 2013. ,
DOI : 10.1371/journal.pgen.1000570
Transport of Magnesium by a Bacterial Nramp-Related Gene, PLoS Genetics, vol.30, issue.6, p.1004429, 2014. ,
DOI : 10.1371/journal.pgen.1004429.s008
Solute Carrier 11 Cation Symport Requires Distinct Residues in Transmembrane Helices 1 and 6, Journal of Biological Chemistry, vol.445, issue.15, pp.9651-9658, 2008. ,
DOI : 10.1016/S1359-6446(04)03363-X
Nramp, Curr Top Membr, vol.69, pp.249-293, 2012. ,
DOI : 10.1016/B978-0-12-394390-3.00010-0
URL : https://hal.archives-ouvertes.fr/pasteur-01535407
Molecular Evolutionary Analysis of the Nramp Family, Molecular biology intelligence unit, pp.178-194, 2004. ,
Horizontal Gene Transfer of ?Prototype? Nramp in Bacteria, Journal of Molecular Evolution, vol.57, issue.4, pp.363-376, 2003. ,
DOI : 10.1007/s00239-003-2472-z
The NCBI: Publicly Available Tools and Resources on the Web, Methods Mol Biol, vol.132, pp.301-312, 2000. ,
DOI : 10.1385/1-59259-192-2:301
The MPI Bioinformatics Toolkit for protein sequence analysis, Nucleic Acids Research, vol.34, issue.Web Server, pp.335-339, 2006. ,
DOI : 10.1093/nar/gkl217
MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods, Molecular Biology and Evolution, vol.28, issue.10, pp.2731-2739, 2011. ,
DOI : 10.1093/molbev/msr121
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203626
Multiple Sequence Alignment Using ClustalW and ClustalX, Curr Protoc Bioinform Chapter, vol.266, 2002. ,
DOI : 10.1016/S0076-6879(96)66024-8
SeaView Version 4: A Multiplatform Graphical User Interface for Sequence Alignment and Phylogenetic Tree Building, Molecular Biology and Evolution, vol.27, issue.2, pp.221-224, 2010. ,
DOI : 10.1093/molbev/msp259
URL : https://hal.archives-ouvertes.fr/lirmm-00705187
The Eukaryotic Tree of Life from a Global Phylogenomic Perspective, Cold Spring Harbor Perspectives in Biology, vol.6, issue.5, 2014. ,
DOI : 10.1101/cshperspect.a016147
The origin and early evolution of eukaryotes in the light of phylogenomics, Genome Biology, vol.11, issue.5, p.209, 2010. ,
DOI : 10.1186/gb-2010-11-5-209
The Revised Classification of Eukaryotes, Journal of Eukaryotic Microbiology, vol.56, issue.5, pp.429-493, 2012. ,
DOI : 10.1016/j.ympev.2010.04.020
Mediates Iron Uptake, Biochemistry, vol.50, issue.29, pp.6340-6355, 2011. ,
DOI : 10.1021/bi200343h
URL : https://hal.archives-ouvertes.fr/pasteur-00720832
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0, Systematic Biology, vol.59, issue.3, pp.307-321, 2010. ,
DOI : 10.1093/sysbio/syq010
URL : https://hal.archives-ouvertes.fr/lirmm-00511784
Phylo-mLogo: an interactive and hierarchical multiple-logo visualization tool for alignment of many sequences, BMC Bioinformatics, vol.8, issue.1, p.63, 2007. ,
DOI : 10.1186/1471-2105-8-63
MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes, Structure, vol.23, issue.7, pp.1350-1361, 2015. ,
DOI : 10.1016/j.str.2015.05.006
The PyMOL Molecular Graphics System. DeLano Scientific, 2002. ,
Flexible structure alignment by chaining aligned fragment pairs allowing twists, Bioinformatics, vol.19, issue.Suppl 2, pp.246-255, 2003. ,
DOI : 10.1093/bioinformatics/btg1086
ModBase, a database of annotated comparative protein structure models, and associated resources, Nucleic Acids Research, vol.39, issue.Database, pp.465-474, 2011. ,
DOI : 10.1093/nar/gkq1091
URL : https://hal.archives-ouvertes.fr/pasteur-01414232
ConTemplate Suggests Possible Alternative Conformations for a Query Protein of Known Structure, Structure, vol.23, issue.11, pp.2162-2170, 2015. ,
DOI : 10.1016/j.str.2015.08.018
Transmembrane Topology of the Mammalian Slc11a2 Iron Transporter, Biochemistry, vol.48, issue.35, pp.8422-8434, 2009. ,
DOI : 10.1021/bi900606y
URL : https://hal.archives-ouvertes.fr/pasteur-00819949
Plasma membrane-localized transporter for aluminum in rice, Proceedings of the National Academy of Sciences, vol.143, issue.3, pp.18381-18385, 2010. ,
DOI : 10.1104/pp.106.093005
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972927
Identification of mutations allowing Natural Resistance Associated Macrophage Proteins (NRAMP) to discriminate against cadmium, The Plant Journal, vol.271, issue.4, pp.625-637, 2015. ,
DOI : 10.1074/jbc.271.38.23203
Sites Control Conformational Change in a Neurotransmitter Transporter Homolog, Journal of Biological Chemistry, vol.46, issue.3, pp.1456-1471, 2016. ,
DOI : 10.1002/(SICI)1097-0134(199604)24:4<433::AID-PROT3>3.0.CO;2-F
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids, Nucleic Acids Research, vol.38, issue.Web Server, pp.529-533, 2010. ,
DOI : 10.1093/nar/gkq399
gene, British Journal of Haematology, vol.4, issue.4, pp.492-495, 2012. ,
DOI : 10.1182/blood-2004-07-2966
A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload, Blood Cells, Molecules, and Diseases, vol.47, issue.4, pp.243-248, 2011. ,
DOI : 10.1016/j.bcmd.2011.07.004
URL : https://hal.archives-ouvertes.fr/hal-00739367
Not all DMT1 mutations lead to iron overload, Blood Cells, Molecules, and Diseases, vol.43, issue.2, pp.199-201, 2009. ,
DOI : 10.1016/j.bcmd.2009.05.003
Mutations in the Gene Encoding DMT1: Clinical Presentation and Treatment, Seminars in Hematology, vol.46, issue.4, pp.358-370, 2009. ,
DOI : 10.1053/j.seminhematol.2009.06.005
Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2), Blood, vol.107, issue.1, pp.349-354, 2006. ,
DOI : 10.1182/blood-2005-06-2477
Natural History of Recessive Inheritance of DMT1 Mutations, The Journal of Pediatrics, vol.152, issue.1, pp.136-139, 2008. ,
DOI : 10.1016/j.jpeds.2007.08.041
Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload, Blood, vol.105, issue.3, pp.1337-1342, 2005. ,
DOI : 10.1182/blood-2004-07-2966
Molecular mechanism of ligand recognition by membrane transport protein, Mhp1, The EMBO Journal, vol.33, issue.16, pp.1831-1844, 2014. ,
DOI : 10.15252/embj.201387557
Author response, eLife, vol.43, 2015. ,
DOI : 10.7554/eLife.09410.014
Diversity in protein domain superfamilies, Current Opinion in Genetics & Development, vol.35, pp.40-49, 2015. ,
DOI : 10.1016/j.gde.2015.09.005
URL : http://doi.org/10.1016/j.gde.2015.09.005
Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms, Frontiers in Pharmacology, vol.33, p.183, 2015. ,
DOI : 10.1093/nar/gki524
The Red Queen's long race: human adaptation to pathogen pressure, Current Opinion in Genetics & Development, vol.29, pp.31-38, 2014. ,
DOI : 10.1016/j.gde.2014.07.004
Human calprotectin is an iron-sequestering host-defense protein, Nature Chemical Biology, vol.145, issue.10, pp.765-771, 2015. ,
DOI : 10.1016/0003-2697(71)90405-2
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575267
Metal limitation and toxicity at the interface between host and pathogen, FEMS Microbiology Reviews, vol.38, issue.6, pp.1235-1249, 2014. ,
DOI : 10.1111/1574-6976.12087
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227937
Manganese acquisition and homeostasis at the host-pathogen interface, Frontiers in Cellular and Infection Microbiology, vol.3, p.91, 2013. ,
DOI : 10.3389/fcimb.2013.00091
URL : http://doi.org/10.3389/fcimb.2013.00091
Iron in innate immunity: starve the invaders, Current Opinion in Immunology, vol.21, issue.1, pp.63-67, 2009. ,
DOI : 10.1016/j.coi.2009.01.011
Iron homeostasis in host defence and inflammation, Nature Reviews Immunology, vol.56, issue.8, pp.500-510, 2015. ,
DOI : 10.1128/AAC.01197-12
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801113
Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux, Journal of Cell Science, vol.128, issue.17, pp.3304-3316, 2015. ,
DOI : 10.1242/jcs.173153
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582194
Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease, Genes and Immunity, vol.100, issue.8, pp.691-698, 2007. ,
DOI : 10.1038/sj.gene.6364435
Detection of a novel intracellular microbiome, pp.286-318, 2014. ,
Mycoavidus cysteinexigens gen. nov., sp. nov., an endohyphal bacterium isolated from a soil isolate of the fungus Mortierella elongata, International Journal of Systematic and Evolutionary Microbiology, vol.66, issue.5, 2016. ,
DOI : 10.1099/ijsem.0.000990
The first external loop of the metal ion transporter DCT1 is involved in metal ion binding and specificity, Proceedings of the National Academy of Sciences, vol.43, issue.4-5, pp.10694-10699, 2003. ,
DOI : 10.1016/S0197-0186(03)00032-9
Recent progress in structure???function analyses of Nramp proton-dependent metal-ion transportersThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB ??? Membrane Proteins in Health and Disease., Biochemistry and Cell Biology, vol.84, issue.6, pp.960-978, 2006. ,
DOI : 10.1139/o06-193
-coupled Iron Uptake with Concomitant Uncoupled Cation Currents, Journal of Biological Chemistry, vol.74, issue.49, pp.35089-35094, 1999. ,
DOI : 10.1016/S0006-3495(96)79506-1
URL : https://hal.archives-ouvertes.fr/hal-01400043
is a pH-dependent transporter of manganese, iron, cobalt and nickel, Biochemical Journal, vol.385, issue.1, pp.225-232, 2005. ,
DOI : 10.1042/BJ20040836
Cloning and characterization of a mammalian proton-coupled metal-ion transporter, Nature, vol.388, issue.6641, pp.482-488, 1997. ,
DOI : 10.1038/41343
Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes, J Exp Biol, vol.204, pp.1053-1061, 2001. ,
Transition metal homeostasis: from yeast to human disease, BioMetals, vol.273, issue.44, pp.785-809, 2011. ,
DOI : 10.1074/jbc.273.44.28713
The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese, PLOS Genetics, vol.255, issue.3, p.1004977, 2015. ,
DOI : 10.1371/journal.pgen.1004977.s018
Sided Functions of an Arginine???Agmatine Antiporter Oriented in Liposomes, Biochemistry, vol.51, issue.8, pp.1577-1585, 2012. ,
DOI : 10.1021/bi201897t
The NRAMP family of metal-ion transporters, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1763, issue.7, pp.609-620, 2006. ,
DOI : 10.1016/j.bbamcr.2006.05.007
coupled membrane transport using fluorescence probes, Anal. Methods, vol.275, issue.1, pp.44-46, 2012. ,
DOI : 10.1074/jbc.275.2.1023
Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter, Molecular Microbiology, vol.67, issue.5, pp.1065-1078, 2000. ,
DOI : 10.1083/jcb.130.4.821
The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen, Molecular Microbiology, vol.67, issue.5, pp.1085-1100, 2000. ,
DOI : 10.1016/S1367-5931(99)80031-3
Roles of the Yfe and Feo transporters of Yersinia pestis in iron uptake and intracellular growth, BioMetals, vol.37, issue.3-4, pp.699-703, 2007. ,
DOI : 10.1128/9781555816544.ch15
and is regulated by manganese via the Fur protein, Molecular Microbiology, vol.67, issue.2, pp.399-409, 2009. ,
DOI : 10.1111/j.1365-2958.2009.06650.x
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene, Nature Genetics, vol.4, issue.4, pp.383-386, 1997. ,
DOI : 10.1006/geno.1996.0177
The Mutation F227I Increases the Coupling of Metal Ion Transport in DCT1, Journal of Biological Chemistry, vol.11, issue.51, pp.53056-53061, 2004. ,
DOI : 10.3109/09687689409161024
How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters, The Journal of Physiology, vol.449, issue.Suppl, pp.863-869, 2014. ,
DOI : 10.1038/nature06133
A structural perspective of compensatory evolution, Current Opinion in Structural Biology, vol.26, pp.104-112, 2014. ,
DOI : 10.1016/j.sbi.2014.05.004