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The Virus way to Influence Cell Fate, Survive and Persist

Abstract : In order to thwart a viral infection, the host has developed an integrated defense network that includes innate and adaptive immunity as well as regulated cell death (RCD), which appears to represent an ancestral defence mechanism for the host. Indeed, RCD is important to control several aspects of the cell fate in various situations, from embryonic development and adult tissue homoeostasis development, to stress response, including viral infection, where different but complementary highly regulated arms of the complex RCD process exist and can be activated, with various consequences. In order for a host to cope with a viral infection, RCD can play a critical role in the elimination of virus-infected cells and/or to control the cell-to-cell viral dissemination to protect the whole organism. During the pathogen-host co-evolution, viruses have developed various strategies to counteract defenses of the host and, among other things, they have acquired the capacity to subvert host-cell RCD. For some viruses, disabling host-cell RCD, at least for some time, could represent an important step in the replication cycle as an effort to prolong their own survival and possibly establish a persistent infection, which can lead to chronic diseases. On the other hand, other viruses may take advantage of RCD to facilitate shedding and disseminate more efficiently in the host or to prevent the presentation of viral antigens to the immune cells. By encoding numerous proteins that either are homologs to cellular apoptosis-regulatory factors or interfere with cellular proteins that control RCD-related pathways, several different viruses are able to induce or modulate the different cellular pathways that control RCD. Virus modulation of cell death participates in the pathological process associated with several human diseases; therefore understanding mechanisms and consequences of virus interactions with the host cell-death machinery is essential to understand potentially pathologically relevant consequences that will help in the design of intervention strategies and the development of antiviral therapies.
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Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Tuesday, August 15, 2017 - 7:59:06 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM


  • HAL Id : pasteur-01574591, version 1



Marc Desforges, Mathieu Meessen-Pinard, Pierre J Talbot. The Virus way to Influence Cell Fate, Survive and Persist. Modulating Regulated Cell Death, Nova publishing, pp.35-74, 2017. ⟨pasteur-01574591⟩



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