The singular epidemiology of HPV infection among French Guianese women with normal cytology

Antoine Adenis (1) , Valentin Dufit (1) , Maylis Douine (1) , Fatiha Najioullah (2) , Vincent Molinie (3) , Dominique Catherine (3) , Odile Kilié (2) , Nadia Thomas (4) , Jean-Luc Luc Deshayes (5) , Paul Brousse (6) , Hatem Ben Amor (6) , Remy Pignoux (6) , Gabriel Carles (7) , Claire Grenier (6) , Vincent Lacoste (8) , Raymond Cesaire (2) , Mathieu Nacher (1)

1 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
2 Laboratoire de Virologie [Fort-de-France, Martinique]
3 Service d'anatomopathologie [Fort de France, Martinique]
4 Service de Gynecologie Obstétrique [Cayenne]
5 AGDOC - Association de Dépistage Organisé des Cancers de Guyane
6 Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française]
7 Centre Hospitalier de l'Ouest Guyanais
8 Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française]

BACKGROUND: In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana. METHODS: Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit. RESULTS: Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%. CONCLUSIONS: HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.

Keywords: Human papillomavirus; Normal cytology; Prevalence; French Guiana; Genotype

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Santé publique et épidémiologie; Life Sciences [q-bio]; Microbiology and Parasitology

Antoine Adenis, Valentin Dufit, Maylis Douine, Fatiha Najioullah, Vincent Molinie, et al.. The singular epidemiology of HPV infection among French Guianese women with normal cytology. BMC Public Health, 2017, 360 (1), pp.1385 - 1385. ⟨10.1186/s12889-017-4181-3⟩. ⟨pasteur-01583545⟩