HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012

Edith Darcissac (1) , Mathieu Nacher (2, 3) , Leila Adriouch (3) , Alain Berlioz-Arthaud (1) , Rachida Boukhari (4) , Pierre Couppié (3) , Félix Djossou (5) , Damien Donato (1) , Myriam El Guedj (3) , Anne Lavergne (1) , Emmanuelle Papot (3) , Jean-François Pouliquen (1) , Edouard Tanguy (1) , Vincent Vantilcke (4) , Vincent Lacoste (1)

1 Institut Pasteur de la Guyane
2 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
3 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
4 Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni)
5 Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française]

Little information is available on the molecular epidemiologic profile of HIV-1 in French Guiana, the French department with the highest HIV/AIDS incidence. To follow the evolution of HIV-1 diversity, we carried out a molecular analysis of HIV-1 isolates from 305 treatment-naive patients between 2006 and 2012. Protease and reverse-transcriptase sequences were obtained for subtype characterization, polymorphism analysis, and identification of drug resistance mutations. Of 305 HIV-1 strains, 95.1% were subtype B viruses. The overall prevalence of transmitted drug-resistance mutations (TDRMs) was 4.6% (14/305), ranging from 1.9% to 7.1% depending on the year. This study shows a low level of HIV-1 genetic diversity and a moderate prevalence of TDRMs with no evidence of an increasing trend over the study period. Nevertheless, the strong genetic polymorphism observed on both genes may be of concern for long-term treatment of people living with HIV-1 and thus deserves continuous monitoring.

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie; Virology

Edith Darcissac, Mathieu Nacher, Leila Adriouch, Alain Berlioz-Arthaud, Rachida Boukhari, et al.. HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012. AIDS Research and Human Retroviruses, 2016, 32 (8), pp.801 - 811. ⟨10.1089/aid.2016.0048⟩. ⟨pasteur-01583613⟩