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Journal articles
HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012
Edith Darcissac
1
Mathieu Nacher
2, 3
Leila Adriouch
3
Alain Berlioz-Arthaud
1
Rachida Boukhari
4
Pierre Couppié
3
Felix Djossou
5
Damien Donato
1
Myriam Guedj
3
Anne Lavergne
1
Emmanuelle Papot
3
Jean-François Pouliquen
1
Edouard Tanguy
1
Vincent Vantilcke
4
Vincent Lacoste
1, *
*
Corresponding author
Edith Darcissac 1
Author
Mathieu Nacher 2, 3
Author IdHAL : mathieu-nacher ORCID : https://orcid.org/0000-0001-9397-3204
Leila Adriouch 3
Author
Alain Berlioz-Arthaud 1
Author
Myriam El Guedj 3
Author
Anne Lavergne 1
Author IdHAL : anne-lavergne ORCID : https://orcid.org/0000-0002-5304-5574
Emmanuelle Papot 3
Author
Jean-François Pouliquen 1
Author
Edouard Tanguy 1
Author
Vincent Vantilcke 4
Author
Vincent Lacoste 1
Correspondent author IdHAL : vincent-lacoste ORCID : https://orcid.org/0000-0002-3173-4053
1
Institut Pasteur de la Guyane (23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex - French Guiana)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane (Unité de Maladies infectieuses, génétiques, et émergentes - Av des flamboyants 97306 Cayenne - France)
- UAG - Université des Antilles et de la Guyane : EA3593 (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC1424 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
- CHU de Fort de France (France)
- Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
3
Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
4
Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni) (16 bd du Général de Gaulle 97393 Saint-Laurent-du-Maroni - French Guiana)
5
Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française] (Av des flamboyants - B.P 6006 - Cayenne 97306 Cedex - French Guiana)
- Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
Abstract : Little information is available on the molecular epidemiologic profile of HIV-1 in French Guiana, the French department with the highest HIV/AIDS incidence. To follow the evolution of HIV-1 diversity, we carried out a molecular analysis of HIV-1 isolates from 305 treatment-naive patients between 2006 and 2012. Protease and reverse-transcriptase sequences were obtained for subtype characterization, polymorphism analysis, and identification of drug resistance mutations. Of 305 HIV-1 strains, 95.1% were subtype B viruses. The overall prevalence of transmitted drug-resistance mutations (TDRMs) was 4.6% (14/305), ranging from 1.9% to 7.1% depending on the year. This study shows a low level of HIV-1 genetic diversity and a moderate prevalence of TDRMs with no evidence of an increasing trend over the study period. Nevertheless, the strong genetic polymorphism observed on both genes may be of concern for long-term treatment of people living with HIV-1 and thus deserves continuous monitoring.
Document type :
Journal articles
Complete list of metadata
https://hal-riip.archives-ouvertes.fr/pasteur-01583613
Contributor : Vincent Lacoste <>
Submitted on : Thursday, September 7, 2017 - 4:11:58 PM
Last modification on : Friday, July 10, 2020 - 3:34:17 PM
Contributor : Vincent Lacoste <>
Submitted on : Thursday, September 7, 2017 - 4:11:58 PM
Last modification on : Friday, July 10, 2020 - 3:34:17 PM
Identifiers
- HAL Id : pasteur-01583613, version 1
- DOI : 10.1089/aid.2016.0048
- PUBMED : 27009561
Collections
RIIP | PASTEUR | UNIV-AG | RIIP_GUYANE | INSERM
Citation
Edith Darcissac, Mathieu Nacher, Leila Adriouch, Alain Berlioz-Arthaud, Rachida Boukhari, et al.. HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012. AIDS Research and Human Retroviruses, Mary Ann Liebert, 2016, 32 (8), pp.801 - 811. ⟨10.1089/aid.2016.0048⟩. ⟨pasteur-01583613⟩
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