HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012

Edith Darcissac 1 Mathieu Nacher 2, 3 Leila Adriouch 3 Alain Berlioz-Arthaud 1 Rachida Boukhari 4 Pierre Couppié 3 Felix Djossou 5 Damien Donato 1 Myriam Guedj 3 Anne Lavergne 1 Emmanuelle Papot 3 Jean-François Pouliquen 1 Edouard Tanguy 1 Vincent Vantilcke 4 Vincent Lacoste 1, *
* Corresponding author
1 Institut Pasteur de la Guyane
2 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
3 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
4 Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni)
5 Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française]
Abstract : Little information is available on the molecular epidemiologic profile of HIV-1 in French Guiana, the French department with the highest HIV/AIDS incidence. To follow the evolution of HIV-1 diversity, we carried out a molecular analysis of HIV-1 isolates from 305 treatment-naive patients between 2006 and 2012. Protease and reverse-transcriptase sequences were obtained for subtype characterization, polymorphism analysis, and identification of drug resistance mutations. Of 305 HIV-1 strains, 95.1% were subtype B viruses. The overall prevalence of transmitted drug-resistance mutations (TDRMs) was 4.6% (14/305), ranging from 1.9% to 7.1% depending on the year. This study shows a low level of HIV-1 genetic diversity and a moderate prevalence of TDRMs with no evidence of an increasing trend over the study period. Nevertheless, the strong genetic polymorphism observed on both genes may be of concern for long-term treatment of people living with HIV-1 and thus deserves continuous monitoring.
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Edith Darcissac, Mathieu Nacher, Leila Adriouch, Alain Berlioz-Arthaud, Rachida Boukhari, et al.. HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012. AIDS Research and Human Retroviruses, Mary Ann Liebert, 2016, 32 (8), pp.801 - 811. ⟨10.1089/aid.2016.0048⟩. ⟨pasteur-01583613⟩

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