Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements

Kenneth A Stapleford (1) , Gonzalo Moratorio (1) , Rasmus Henningsson (1, 2) , Rubing Chen (3) , Severine Matheus (4) , Antoine Enfissi (4) , Daphna Weissglas-Volkov (5) , Ofer Isakov (5) , Hervé Blanc (1) , Bryan C. Mounce (1) , Myrielle Dupont-Rouzeyrol (6) , Noam Shomron (5) , Scott Weaver (3) , Magnus Fontes (2) , Dominique Rousset (4) , Marco Vignuzzi (1)

1 Populations virales et Pathogenèse - Viral Populations and Pathogenesis
2 IGDA - International Group for Data Analysis
3 UTMB - The University of Texas Medical Branch
4 Institut Pasteur de la Guyane
5 Sackler Faculty of Medicine
6 Institut Pasteur de Nouvelle-Calédonie

Chikungunya virus (CHIKV), an alphavirus and member of the Togaviridae family, is capable of causing severe febrile disease in humans. In December of 2013 the Asian Lineage of CHIKV spread from the Old World to the Americas, spreading rapidly throughout the New World. Given this new emergence in naïve populations we studied the viral genetic diversity present in infected individuals to understand how CHIKV may have evolved during this continuing outbreak.

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology

Kenneth A Stapleford, Gonzalo Moratorio, Rasmus Henningsson, Rubing Chen, Severine Matheus, et al.. Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements. PLoS Neglected Tropical Diseases, 2016, 10 (1), pp.e0004402. ⟨10.1371/journal.pntd.0004402⟩. ⟨pasteur-01634324⟩