Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements

Kenneth Stapleford; Gonzalo Moratorio; Rasmus Henningsson; Rubing Chen; Severine Matheus; Antoine Enfissi; Daphna Weissglas-Volkov; Ofer Isakov; Hervé Blanc; Bryan C. Mounce; Myrielle Dupont-Rouzeyrol; Noam Shomron; Scott Weaver; Magnus Fontes; Dominique Rousset; Marco Vignuzzi

doi:10.1371/journal.pntd.0004402

Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements

Kenneth Stapleford ¹ Gonzalo Moratorio ¹ Rasmus Henningsson ^{1, 2} Rubing Chen ³ Severine Matheus ⁴ Antoine Enfissi ⁴ Daphna Weissglas-Volkov ⁵ Ofer Isakov ⁵ Hervé Blanc ¹ Bryan C. Mounce ¹ Myrielle Dupont-Rouzeyrol ⁶ Noam Shomron ⁵ Scott Weaver ³ Magnus Fontes ² Dominique Rousset ⁴ Marco Vignuzzi ^{1, *}

* Auteur correspondant

1 Populations virales et Pathogenèse

2 IGDA - International Group for Data Analysis

Institut Pasteur [Paris]

3 UTMB - The University of Texas Medical Branch

4 Institut Pasteur de la Guyane

5 Sackler Faculty of Medicine

6 Institut Pasteur de Nouvelle-Calédonie

Abstract : Chikungunya virus (CHIKV), an alphavirus and member of the Togaviridae family, is capable of causing severe febrile disease in humans. In December of 2013 the Asian Lineage of CHIKV spread from the Old World to the Americas, spreading rapidly throughout the New World. Given this new emergence in naïve populations we studied the viral genetic diversity present in infected individuals to understand how CHIKV may have evolved during this continuing outbreak.

Type de document :

Article dans une revue

PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (1), pp.e0004402. 〈10.1371/journal.pntd.0004402〉

Domaine :

Sciences du Vivant [q-bio]

Sciences du Vivant [q-bio] / Microbiologie et Parasitologie

Sciences du Vivant [q-bio] / Microbiologie et Parasitologie / Virologie

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https://hal-riip.archives-ouvertes.fr/pasteur-01634324
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Soumis le : mardi 14 novembre 2017 - 05:23:51
Dernière modification le : lundi 8 octobre 2018 - 17:44:08

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Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements

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