C. Paisan-ruiz, S. Jain, E. Evans, W. Gilks, J. Simon et al., Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, vol.44, issue.4, pp.595-600, 2004.
DOI : 10.1016/j.neuron.2004.10.023

A. Zimprich, S. Biskup, P. Leitner, P. Lichtner, M. Farrer et al., Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, vol.44, issue.4, pp.601-608, 2004.
DOI : 10.1016/j.neuron.2004.11.005

URL : https://doi.org/10.1016/j.neuron.2004.11.005

M. Cookson, Cellular effects of LRRK2 mutations, Biochemical Society Transactions, vol.18, issue.5, pp.1070-1073, 2012.
DOI : 10.1111/j.1469-185X.2009.00082.x

URL : http://www.biochemsoctrans.org/content/ppbiost/40/5/1070.full.pdf

I. Rudenko and M. Cookson, Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications, Neurotherapeutics, vol.70, issue.Suppl. 3, pp.738-50, 2014.
DOI : 10.1007/s00018-012-1061-y

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391379/pdf

I. Mata, W. Wedemeyer, M. Farrer, J. Taylor, and K. Gallo, LRRK2 in Parkinson's disease: protein domains and functional insights, Trends in Neurosciences, vol.29, issue.5, pp.286-93, 2006.
DOI : 10.1016/j.tins.2006.03.006

C. Guedes, L. Ferreira, J. Rosa, M. Coelho, M. Bonifati et al., Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review, Parkinsonism & Related Disorders, vol.16, issue.4, pp.237-279, 2010.
DOI : 10.1016/j.parkreldis.2009.11.004

S. Lesage, A. Leutenegger, P. Ibanez, S. Janin, E. Lohmann et al., LRRK2 Haplotype Analyses in European and North African Families with Parkinson Disease: A Common Founder for the G2019S Mutation Dating from the 13th Century, The American Journal of Human Genetics, vol.77, issue.2, pp.330-332, 2005.
DOI : 10.1086/432422

C. He, J. Holme, and J. Anthony, SNP Genotyping: The KASP Assay, Methods Mol Biology, vol.1145, pp.75-86, 2014.
DOI : 10.1007/978-1-4939-0446-4_7

S. Miller, D. Dykes, and H. Polesky, A simple salting out procedure for extracting DNA from human nucleated cells, Nucleic Acids Research, vol.16, issue.3, p.1215, 1988.
DOI : 10.1093/nar/16.3.1215

URL : https://academic.oup.com/nar/article-pdf/16/3/1215/4063153/16-3-1215.pdf

N. Change, G. Mercier, and G. Lucotte, Gene in Southwest European, North African, and Sephardic Jewish Subjects, Genetic Testing, vol.12, issue.3, pp.333-342, 2008.
DOI : 10.1089/gte.2007.0098

H. Tomiyama, Y. Li, M. Funayama, K. Hasegawa, H. Yoshino et al., Clinicogenetic study of mutations inLRRK2 exon 41 in Parkinson's disease patients from 18 countries, Movement Disorders, vol.104, issue.8, pp.1102-1110, 2006.
DOI : 10.1212/01.WNL.0000125015.06989.DB

S. Lesage, P. Ibanez, E. Lohmann, P. Pollak, F. Tison et al., G2019S LRRK2 mutation in French and North African families with Parkinson's disease, Annals of Neurology, vol.77, issue.5, pp.784-791, 2005.
DOI : 10.1016/S0140-6736(05)17829-5

L. Ishihara, R. Gibson, L. Warren, R. Amouri, K. Lyons et al., Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families, Movement Disorders, vol.65, issue.1, pp.55-61, 2007.
DOI : 10.1017/S0317167100000068

L. Warren, R. Gibson, L. Ishihara, R. Elango, Z. Xue et al., A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease, Parkinsonism & Related Disorders, vol.14, issue.1, pp.77-80, 2008.
DOI : 10.1016/j.parkreldis.2007.02.001

M. Hulihan, L. Ishihara-paul, J. Kachergus, L. Warren, R. Amouri et al., LRRK2 Gly2019Ser penetrance in Arab???Berber patients from Tunisia: a case-control genetic study, The Lancet Neurology, vol.7, issue.7, pp.591-595, 2008.
DOI : 10.1016/S1474-4422(08)70116-9

J. Trinh, R. Amouri, J. Duda, J. Morley, M. Read et al., A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism, Neurobiology of Aging, vol.35, issue.5, pp.1125-1156, 2014.
DOI : 10.1016/j.neurobiolaging.2013.11.015

J. Yuan, Z. Wen, C. Gu, and D. Wang, Introduction of high throughput and cost effective SNP genotyping platforms in soybean, Plant Genet Genomics Biotechnol, vol.1, issue.3, pp.90-94, 2014.

A. Braae, C. Thompson, and K. Morgan, Comparison of custom designed KASP and TaqMan genotyping assays for a rare genetic variant identifed through resequencing GWAS loci. LGC, University of Nottingham -app note:2014. https://www.lgcgroup.com

L. Pihlstrom, A. Rengmark, K. Bjornara, N. Dizdar, C. Fardell et al., Fine mapping and resequencing of the PARK16 locus in Parkinson???s disease, Journal of Human Genetics, vol.2, issue.7, pp.357-62, 2015.
DOI : 10.1038/nn.3801

I. Schmitt, U. Wullner, J. Van-rooyen, H. Khazneh, J. Becker et al., Variants in the 3???UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression, European Journal of Human Genetics, vol.7, issue.12, pp.1265-1274, 2012.
DOI : 10.1093/hmg/ddq469

J. Blanckenberg, C. Ntsapi, J. Carr, and S. Bardien, EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa, Neurobiology of Aging, vol.35, issue.2, pp.445-441, 2014.
DOI : 10.1016/j.neurobiolaging.2013.08.023

B. Benitez, S. Jin, R. Guerreiro, R. Graham, J. Lord et al., Missense variant in TREML2 protects against Alzheimer's disease, Neurobiology of Aging, vol.35, issue.6, pp.1510-1519, 2014.
DOI : 10.1016/j.neurobiolaging.2013.12.010

URL : https://doi.org/10.1016/j.neurobiolaging.2013.12.010

M. Allen, M. Kachadoorian, M. Carrasquillo, A. Karhade, L. Manly et al., Late-onset Alzheimer disease risk variants mark brain regulatory loci, Neurology Genetics, vol.1, issue.2, p.15, 2015.
DOI : 10.1212/NXG.0000000000000012

URL : https://doi.org/10.1212/nxg.0000000000000012

M. Keogh, W. Wei, I. Wilson, J. Coxhead, S. Ryan et al., Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource, Genome Research, vol.35, issue.1, pp.165-73, 2017.
DOI : 10.1016/j.ajhg.2011.05.029

I. Fogh, A. Ratti, C. Gellera, K. Lin, C. Tiloca et al., A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis, Human Molecular Genetics, vol.23, issue.8, pp.2220-2251, 2014.
DOI : 10.1093/hmg/ddt587

E. Ilaecoc, Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies, Lancet Neurol, vol.13, issue.9, pp.893-903, 2014.

C. Bettencourt, D. Hensman-moss, M. Flower, S. Wiethoff, A. Brice et al., DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases, Annals of Neurology, vol.137, issue.pt 2, pp.983-90, 2016.
DOI : 10.1002/ijc.28940

URL : https://hal.archives-ouvertes.fr/hal-01313687