G. Kuttan, P. Pratheeshkumar, K. A. Manu, R. D. Kuttan, and F. Bray, Inhibition of tumor progression by naturally occurring terpenoids Cancer incidence and mortality worldwide: Sources, methods and major patterns in globocan 2012, Pharm. Biol. J.; Soerjomataram, I.; Dikshit, R.; Eser, S.; Mathers, C Int. J. Cancer, vol.49, issue.136, pp.995-1007, 2011.

A. Bhanot, R. S. Malleshappa, and N. N. , Natural sources as potential anti-cancer agents: A review, Phytomedicine, vol.3, pp.9-26, 2011.

S. M. Hussain, S. Fareed, S. Ansari, and M. S. Saba, Marine natural products: A lead for anti-cancer, Indian J. Mar. Sci, vol.41, pp.27-39, 2012.

S. Goulitquer, P. Potin, and T. Tonon, Mass Spectrometry-Based Metabolomics to Elucidate Functions in Marine Organisms and Ecosystems, Marine Drugs, vol.70, issue.12, pp.849-880, 2012.
DOI : 10.1016/j.phytochem.2008.12.021
URL : https://hal.archives-ouvertes.fr/hal-00925443

V. Schwarzenberg, K. Vollmar, and A. M. , Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy, Cancer Letters, vol.332, issue.2, pp.295-303
DOI : 10.1016/j.canlet.2010.07.004

G. Schwartsmann, A. B. Da-rocha, R. G. Berlinck, and J. Jimeno, Marine organisms as a source of new anticancer agents, Marine natural products, pp.221-225, 2001.
DOI : 10.1016/S1470-2045(00)00292-8

E. Ioannou and V. Roussis, Natural products from seaweeds In Plant-Derived Natural Products, pp.51-81, 2009.

D. H. Lee, O. G. Pissibanganga, K. Ko, J. I. Seo, and Y. K. Choo, Anticancer effects of different seaweeds on human colon and breast cancers, Mar. Drugs, vol.12, pp.4898-4911, 2014.

R. C. Pereira and L. Costa-lotufo, Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives, Revista Brasileira de Farmacognosia, vol.22, issue.4, pp.894-905, 2012.
DOI : 10.1590/S0102-695X2012005000077

H. Eric, D. F. Andrianasolo, S. Cornell-kennon, and H. G. William, DNA methyl transferase inhibiting halogenated monoterpenes from the madagascar red marine alga Portieria hornemannii, J. Nat. Prod, vol.69, pp.576-579, 2006.

A. Gonzalez-coloma, Cytotoxic activity of halogenated monoterpenes from Plocamium cartilagineum, Z. Naturforsch, vol.59, pp.339-344, 2004.

E. M. Antunes, A. F. Afolayan, M. T. Chiwakata, J. Fakee, M. G. Knott et al., Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum, Phytochemistry, vol.72, issue.8, pp.769-772, 2011.
DOI : 10.1016/j.phytochem.2011.02.003

M. G. Knott, H. Mkwananzi, C. E. Arendse, D. T. Hendricks, J. J. Bolton et al., Plocoralides A???C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza, Phytochemistry, vol.66, issue.10, pp.1108-1112, 2005.
DOI : 10.1016/j.phytochem.2005.03.029

J. De-la-mare, J. Lawson, M. Chiwakata, D. Beukes, A. Edkins et al., Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro, Investigational New Drugs, vol.59, issue.3, pp.2187-2200, 2012.
DOI : 10.1038/374814a0

R. Capon, L. Engelhardt, E. Ghisalberti, P. Jefferies, V. Patrick et al., species, Australian Journal of Chemistry, vol.37, issue.3, pp.537-544, 1984.
DOI : 10.1071/CH9840537
URL : https://hal.archives-ouvertes.fr/hal-01577005

M. I. Errea and M. C. Matulewicz, Cold water-soluble polysaccharides from tetrasporic Pterocladia capillacea, Phytochemistry, vol.37, issue.4, pp.1075-1078, 1994.
DOI : 10.1016/S0031-9422(00)89531-X

M. I. Errea and M. C. Matulewicz, Unusual structures in the polysaccharides from the red seaweed Pterocladiella capillacea (Gelidiaceae, Gelidiales), Carbohydrate Research, vol.338, issue.9, pp.943-953, 2003.
DOI : 10.1016/S0008-6215(03)00037-5

M. I. Errea and M. C. Matulewicz, Hot water-soluble polysaccharides from tetrasporic Pterocladia capillacea, Phytochemistry, vol.42, issue.4, pp.1071-1073, 1996.
DOI : 10.1016/0031-9422(96)00047-7

A. Rao and I. A. Bekheet, Preparation of agar-agar from the red seaweed Pterocladia capillacea off the coast of Alexandria, Egypt. Appl. Environ. Microbiol, vol.32, pp.479-482, 1976.

S. R. Oliveira, A. E. Nascimento, M. E. Lima, Y. Leite, and N. M. Benevides, Purification and characterisation of a lectin from the red marine alga Pterocladiella capillacea (S.G. Gmel.) Santel. & Hommers., Revista Brasileira de Bot??nica, vol.25, issue.4, pp.397-403, 2002.
DOI : 10.1590/S0100-84042002012000003

F. B. Whitfield, F. Helidoniotis, K. J. Shaw, and D. Svoronos, Distribution of Bromophenols in Species of Marine Algae from Eastern Australia, Journal of Agricultural and Food Chemistry, vol.47, issue.6, pp.2367-2373, 1999.
DOI : 10.1021/jf981080h

S. Sciuto, R. Chillemi, and M. Piattelli, Onium Compounds from the Red Alga Pterocladia capillacea, Journal of Natural Products, vol.51, issue.2, pp.322-325, 1988.
DOI : 10.1021/np50056a023

R. S. Norton, R. G. Warren, and R. J. Wells, Three new polyhalogenated monoterpenes from Plocamium species, Tetrahedron Letters, vol.18, issue.44, pp.3905-3908, 1977.
DOI : 10.1016/S0040-4039(01)83387-6

P. A. Muller and K. H. Vousden, p53 mutations in cancer, Nature Cell Biology, vol.19, issue.1, pp.2-8
DOI : 10.1038/sj.onc.1201857

S. Gupta, J. Kim, S. Prasad, and B. Aggarwal, Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals, Cancer and Metastasis Reviews, vol.16, issue.Pt 3, pp.405-434, 2010.
DOI : 10.1002/biof.5520290102

S. Sreevalsan and S. Safe, Reactive Oxygen Species and Colorectal Cancer, Current Colorectal Cancer Reports, vol.20, issue.5, pp.350-357
DOI : 10.1016/j.ccr.2011.09.012

L. S. Steelman, W. H. Chappell, S. L. Abrams, C. R. Kempf, J. Long et al., Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging, Aging, vol.3, issue.3, pp.192-222, 2011.
DOI : 10.18632/aging.100296

X. Dolcet, D. Llobet, J. Pallares, and X. Matias-guiu, Nf-kb in development and progression of human cancer. Virchows Arch, pp.475-482, 2005.

R. J. Thoppil and A. Bishayee, Terpenoids as potential chemopreventive and therapeutic agents in liver cancer, World Journal of Hepatology, vol.3, issue.9, pp.228-249, 2011.
DOI : 10.1002/biof.5520230302

C. Zhang and Y. Liu, Targeting cancer with sesterterpenoids: the new potential antitumor drugs, Journal of Natural Medicines, vol.64, issue.30, pp.255-266
DOI : 10.1021/np0101494

T. Rabi and A. Bishayee, Terpenoids and breast cancer chemoprevention, Breast Cancer Research and Treatment, vol.67, issue.2, pp.223-239, 2009.
DOI : 10.1080/07315724.1992.10718253

S. Cheng, S. Wang, Y. Ou, and C. Duh, Mollisolactones A and B, novel dinormonoterpenes from the soft coral Sinularia mollis, Bioorganic & Medicinal Chemistry Letters, vol.26, issue.3, pp.879-881
DOI : 10.1016/j.bmcl.2015.12.076

H. Bo, A. P. Van-den-heuvel, V. P. Varun, Z. Shengliang, and S. E. Wafik, Targeting tumor suppressor p53 for cancer therapy: Strategies, challenges and opportunities, Curr. Drug Targets, vol.15, pp.80-89, 2014.

D. Pavlou and A. Kirmizis, Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway, Apoptosis, vol.23, issue.5381, pp.298-311, 2015.
DOI : 10.1016/j.tcb.2013.08.003

J. Meng, H. H. Zhang, C. X. Zhou, C. Li, F. Zhang et al., The histone deacetylase inhibitor trichostatin a induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways, Oncol. Rep, vol.28, pp.384-388, 2012.

D. Thapa, D. Babu, M. Park, M. Kwak, Y. Lee et al., Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells, Biochemical Pharmacology, vol.80, issue.1, pp.62-71, 2010.
DOI : 10.1016/j.bcp.2010.03.008

G. K. Schwartz and M. A. Shah, Targeting the Cell Cycle: A New Approach to Cancer Therapy, Journal of Clinical Oncology, vol.23, issue.36, pp.9408-9421, 2005.
DOI : 10.1200/JCO.2005.01.5594

R. W. Johnstone, A. A. Ruefli, and S. W. Lowe, Apoptosis, Cell, vol.108, issue.2, pp.153-164, 2002.
DOI : 10.1016/S0092-8674(02)00625-6

I. M. Ghobrial, T. E. Witzig, and A. A. Adjei, Targeting Apoptosis Pathways in Cancer Therapy, CA: A Cancer Journal for Clinicians, vol.55, issue.3, pp.178-194, 2005.
DOI : 10.3322/canjclin.55.3.178

R. Wong, Apoptosis in cancer: from pathogenesis to treatment, Journal of Experimental & Clinical Cancer Research, vol.30, issue.1, 2011.
DOI : 10.1016/j.bbrc.2007.04.134

J. L. Koff, S. Ramachandiran, and L. Bernal-mizrachi, A Time to Kill: Targeting Apoptosis in Cancer, International Journal of Molecular Sciences, vol.122, issue.2, pp.2942-2955
DOI : 10.1021/jm400216d

O. 'brien, M. A. Kirby, and R. , Apoptosis: A review of pro-apoptotic and anti-apoptotic pathways and dysregulation in disease, Journal of Veterinary Emergency and Critical Care, vol.10, issue.(3), pp.572-585, 2008.
DOI : 10.1111/j.1476-4431.2008.00363.x

D. Brenner and T. W. Mak, Mitochondrial cell death effectors, Current Opinion in Cell Biology, vol.21, issue.6, pp.871-877, 2009.
DOI : 10.1016/j.ceb.2009.09.004

D. R. Mcilwain, T. Berger, and T. W. Mak, Caspase Functions in Cell Death and Disease, Cold Spring Harbor Perspectives in Biology, vol.5, issue.4, 2013.
DOI : 10.1101/cshperspect.a008656

A. G. Porter and R. Janicke, Emerging roles of caspase-3 in apoptosis, Cell Death & Differentiation, vol.6, issue.2, pp.99-104, 1999.
DOI : 10.1038/sj.cdd.4400476

W. L. Kan, C. Yin, H. X. Xu, G. Xu, K. K. To et al., cell cycle arrest and apoptosis, International Journal of Cancer, vol.9, issue.3, pp.707-716, 2013.
DOI : 10.1038/nrc2694

C. Weidner, M. Rousseau, R. J. Micikas, C. Fischer, A. Plauth et al., Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria, Journal of Natural Products, vol.79, issue.1, pp.2-12, 2016.
DOI : 10.1021/acs.jnatprod.5b00072

S. A. Dyshlovoy, R. Madanchi, J. Hauschild, K. Otte, W. H. Alsdorf et al., The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells, BMC Cancer, vol.27, issue.50, p.93, 2017.
DOI : 10.3390/md14060115

J. Y. Fang and B. C. Richardson, The MAPK signalling pathways and colorectal cancer, The Lancet Oncology, vol.6, issue.5, pp.322-327, 2005.
DOI : 10.1016/S1470-2045(05)70168-6

S. A. Danielsen, P. W. Eide, A. Nesbakken, T. Guren, E. Leithe et al., Portrait of the PI3K/AKT pathway in colorectal cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1855, issue.1, pp.104-121, 2015.
DOI : 10.1016/j.bbcan.2014.09.008

K. Sakamoto and S. Maeda, Targeting NF-??B for colorectal cancer, Expert Opinion on Therapeutic Targets, vol.21, issue.4, pp.593-601, 2010.
DOI : 10.1016/j.immuni.2004.08.009

K. Sakamoto, S. Maeda, Y. Hikiba, H. Nakagawa, Y. Hayakawa et al., Constitutive NF-??B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth, Clinical Cancer Research, vol.15, issue.7, pp.2248-2258, 2009.
DOI : 10.1158/1078-0432.CCR-08-1383

P. Godwin, A. M. Baird, S. Heavey, M. P. Barr, K. J. O-'byrne et al., Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy, Frontiers in Oncology, vol.3, issue.3, p.120
DOI : 10.3389/fonc.2013.00120

M. Los and H. Walczak, Caspases: Their Role in Cell Death and Cell Survival, Molecular Biology Intelligence Unit, vol.24, 2002.

Z. Lu, S. Xu, and . Erk1, ERK1/2 MAP kinases in cell survival and apoptosis, IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), vol.58, issue.11, pp.621-631, 2006.
DOI : 10.1080/15216540600957438

C. Lv, W. Sun, H. Sun, S. Wei, R. Chen et al., Asperolide A, a Marine-Derived Tetranorditerpenoid, Induces G2/M Arrest in Human NCI-H460 Lung Carcinoma Cells, Is Mediated by p53-p21 Stabilization and Modulated by Ras/Raf/MEK/ERK Signaling Pathway, Marine Drugs, vol.33, issue.2, pp.316-331, 2013.
DOI : 10.1016/j.biomaterials.2011.11.045

C. Lv, Y. Hong, L. Miao, C. Li, G. Xu et al., Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway, Cell Death and Disease, vol.54, issue.12
DOI : 10.1080/15216540701636287

X. Peng and V. Gandhi, ROS-activated anticancer prodrugs: a new strategy for tumor-specific damage, Therapeutic Delivery, vol.90, issue.7, pp.823-833
DOI : 10.1002/chem.201200075

G. Liou and P. Storz, Reactive oxygen species in cancer, Free Radical Research, vol.29, issue.5, pp.479-496, 2010.
DOI : 10.1128/MCB.00077-09

V. Nogueira, Y. Park, C. Chen, P. Xu, M. Chen et al., Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis, Cancer Cell, vol.14, issue.6, pp.458-470, 2008.
DOI : 10.1016/j.ccr.2008.11.003