Carcinome neuroendocrine thymique: à propos d’un cas et revue de la littérature

Abstract : Thymic neuroendocrine tumors (TNET) are rare, with little-known prognosis. This study aims to report a case of TNET and to highlight the diagnostic and therapeutic difficulties in low-resource settings. A 60-year-old man presented with chest pain, greasy cough and recent weight loss. Chest CT scan showed anterior mediastinal tissue mass. Histologic evaluation of a 4 months-biopsy specimen obtained from anterior mediastinotomy showed a well differentiated TNET, labeled intensely positive for chromogranin and synaptophysin. The search for other neuroendocrine tumors and the extent of extension were negative. The tumor was immediately inextricable and radiation therapy was unavailable. The patient underwent two lines of first line chemotherapy. At 16 months follow-up, the patient was asymptomatic but showed tumor progression. The diagnosis of TNET may be delayed when immunohistochemistry is not routinely performed. Chemotherapy is associated with symptoms improvement in palliative care situation.
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Andriatsihoarana Ramahandrisoa, Nomeharisoa Hasiniatsy, Valéry Refeno, Clairette Raharisolo Vololonantenaina, Andriamihaja Rakotoarisoa, et al.. Carcinome neuroendocrine thymique: à propos d’un cas et revue de la littérature. The Pan African medical journal, Kampala, Uganda : African Field Epidemiology Network, 2017, 26, pp.25. ⟨10.11604/pamj.2017.26.25.11500⟩. ⟨pasteur-01670435⟩

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