Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages - Archive ouverte HAL Access content directly
Journal Articles The Pan African Medical Journal Year : 2017

Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages

(1, 2, 3) , (1) , (1) , (1, 3) , (1) , (1) , (1) , (1) , (1, 2, 3)
1
2
3

Abstract

Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM. The aim of the present study was to identify the distribution of chromosome abnormalities among Tunisian couples with RM referred to the Department of Cytogenetic at the Pasteur Institute of Tunis (Tunisia) during the last five years. Standard cytogenetic analysis was carried out in a total of 163 couples presenting with two or more spontaneous abortions. Karyotypes were analyzed by R-banding. We identified 14 chromosomal abnormalities including autosomal reciprocal translocation, Robertsonian translocation, inversion, mosaic aneuploidy and heteromorphysm. The overall prevalence of chromosomal abnormalities was 8.5% in our cohort. This finding underlies the importance of cytogenetic investigations in the routine management of RM.
Fichier principal
Vignette du fichier
PAMJ-28-99.pdf (381 Ko) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

pasteur-01674375 , version 1 (02-01-2018)

Identifiers

Cite

Wiem Ayed, Islem Messaoudi, Zouhour Belghith, Wajih Hammami, Imen Chemkhi, et al.. Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages. The Pan African Medical Journal, 2017, 28, pp.99 - 99. ⟨10.11604/pamj.2017.28.99.11879⟩. ⟨pasteur-01674375⟩

Collections

RIIP RIIP_TUNIS
18 View
76 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More