Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

Abstract : Loss of CD4(+) T cells in the gut is necessary but not sufficient to cause AIDS in animal models, raising the possibility that a differential loss of CD4(+) T-cell subtypes may be important. We found that CD4(+) T cells that produce interleukin (IL)-17, a recently identified lineage of effector CD4(+) T-helper cells, are infected by SIV(mac251)in vitro and in vivo, and are found at lower frequency at mucosal and systemic sites within a few weeks from infection. In highly viremic animals, Th1 cells predominates over Th17 T cells and the frequency of Th17 cells at mucosal sites is negatively correlated with plasma virus level. Because Th17 cells play a central role in innate and adaptive immune response to extracellular bacteria, our finding may explain the chronic enteropathy in human immunodeficiency virus (HIV) infection. Thus, therapeutic approaches that reconstitute an adequate balance between Th1 and Th17 may be beneficial in the treatment of HIV infection.
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01675685
Contributor : Jean-Michel Heraud <>
Submitted on : Thursday, January 4, 2018 - 5:26:34 PM
Last modification on : Tuesday, August 6, 2019 - 3:14:33 PM
Long-term archiving on : Thursday, May 3, 2018 - 7:38:24 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

V Cecchinato, C J Trindade, A Laurence, Jean-Michel Heraud, J Brenchley, et al.. Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. Mucosal Immunology, Nature Pub. Group, 2008, 1 (4), pp.279 - 288. ⟨10.1038/mi.2008.14⟩. ⟨pasteur-01675685⟩

Share

Metrics

Record views

51