Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Understanding TGEV-ETEC Coinfection through the Lens of Proteomics: A Tale of Porcine Diarrhea

Abstract : Porcine diarrhea and gastroenteritis are major causes of piglet mortality that result in devastating economic losses to the industry. A plethora of pathogens can cause these diseases, with TGEV and ETEC being two of the most salient. In this issue, Xia and colleagues use comparative proteomics to shed light on how these microbes interact to cause severe disease [Xia, L., et al., Proteomics Clin. Appl. 2017, 1600137-n/a]. The authors discovered that TGEV induces an EMT-like phenotype that augments cell adhesion proteins that mediate the attachment of ETEC to intestinal epithelial cells. Moreover, coinfection was found to modulate several host proteins that could bolster pathogen persistence. Importantly, the authors observed that ETEC suppresses the production of inflammatory cytokines induced by TGEV, which may in turn promote the long-term survival of both microbes. This article is protected by copyright. All rights reserved.
Document type :
Journal articles
Complete list of metadata
Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, January 19, 2018 - 5:58:00 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM

Links full text




Guillermo Arango Duque, Hamlet Adolfo Acevedo Ospina. Understanding TGEV-ETEC Coinfection through the Lens of Proteomics: A Tale of Porcine Diarrhea. PROTEOMICS - Clinical Applications, Wiley-VCH Verlag, 2017, ⟨10.1002/prca.201700143⟩. ⟨pasteur-01688855⟩



Record views