Occupational solvent exposure and risk of glioma in the INTEROCC study

Geza Benke; Michelle Turner; Sarah Fleming; Jordi Figuerola; Laurel Kincl; Lesley Richardson; Maria Blettner; Martine Hours; Daniel Krewski; David Mclean; Marie-Élise Parent; Siegal Sadetzki; Klaus Schlaefer; Brigitte Schlehofer; Jack Siemiatycki; Martie van Tongeren; Elisabeth Cardis

doi:10.1038/bjc.2017.285

Journal articles

Occupational solvent exposure and risk of glioma in the INTEROCC study

Geza Benke ^{1, *} Michelle Turner ^{2, 3, 4} Sarah Fleming ⁵ Jordi Figuerola ^{3, 2} Laurel Kincl ⁶ Lesley Richardson ⁷ Maria Blettner ⁸ Martine Hours Daniel Krewski ⁴ David Mclean Marie-Élise Parent ⁹ Siegal Sadetzki ^{10, 11} Klaus Schlaefer ¹² Brigitte Schlehofer ¹² Jack Siemiatycki ⁷ Martie van Tongeren ^{13, 14} Elisabeth Cardis ^{3, 2, 15}

* Corresponding author

1 Monash University [Clayton]

2 UPF - Universitat Pompeu Fabra [Barcelona]

3 CIBER de Epidemiología y Salud Pública (CIBERESP)

4 University of Ottawa [Ottawa]

5 University of Leeds

6 OSU - Oregon State University

7 CHUM - Centre Hospitalier de l'Université de Montréal

8 JGU - Johannes Gutenberg - Universität Mainz

9 INRS-IAF - Institut Armand Frappier

10 Sackler Faculty of Medicine

11 Chaim Sheba Medical Center

12 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]

13 IOM - Institute of Occupational Medicine [Edinburgh]

14 University of Manchester [Manchester]

15 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]

Abstract : BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade. METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM. RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour. CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.

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Journal articles

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Life Sciences [q-bio]

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Occupational solvent exposure and risk of glioma in the INTEROCC study

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