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Journal articles
Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia
Abstract : Culex pipiens mosquitoes are infected with Wolbachia (wPip) that cause an important diversity of cytoplasmic incompatibilities (CIs). Functional transgenic studies have implicated the cidA-cidB operon from wPip and its homolog in wMel in CI between infected Drosophila males and uninfected females. However, the genetic basis of the CI diversity induced by different Wolbachia strains was unknown. We show here that the remarkable diversity of CI in the C. pipiens complex is due to the presence, in all tested wPip genomes, of several copies of the cidA-cidB operon, which undergoes diversification through recombination events. In 183 isofemale lines of C. pipiens collected worldwide, specific variations of the cidA-cidB gene repertoires are found to match crossing types. The diversification of cidA-cidB is consistent with the hypothesis of a toxin–antitoxin system in which the gene cidB co-diversifies with the gene cidA, particularly in putative domains of reciprocal interactions.
Cited literature [29 references]
https://hal-riip.archives-ouvertes.fr/pasteur-01728878
Contributor : Abdelhakim Ben Hassine Connect in order to contact the contributor
Submitted on : Monday, March 12, 2018 - 10:39:53 AM
Last modification on : Wednesday, November 17, 2021 - 12:31:29 PM
Long-term archiving on: : Wednesday, June 13, 2018 - 12:51:37 PM
Contributor : Abdelhakim Ben Hassine Connect in order to contact the contributor
Submitted on : Monday, March 12, 2018 - 10:39:53 AM
Last modification on : Wednesday, November 17, 2021 - 12:31:29 PM
Long-term archiving on: : Wednesday, June 13, 2018 - 12:51:37 PM
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