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HIV Type 1 Diversity in the Seychelles

Abstract : Subtype determination and drug resistance-associated mutations (DRM) detection were performed on 40 HIV-1 Western blot-positive sera detected, obtained from consecutive patients resident in the Seychelles and consulting the Communicable Disease Control Unit, HIV reference center, in Victoria Hospital (Mahe) from October 2005 to June 2006. Amplification and sequencing of at least two of the partial reverse transcriptase, protease, and partial envelope genes were successful for all strains. All three genes sequences were obtained for 39 strains. A high degree of subtype or circulating recombinant forms (CRF) was observed for these 39 strains: A-A1 (17 cases), C (10 cases), B (8 cases), CRF02_AG (2 cases), D (1 case) and CRF01_AE (1 case). According to the ANRS 2006 DRM list and algorithm, none of the 40 isolates was found to be resistant to any protease or reverse transcriptase inhibitors.
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Richter Razafindratsimandresy, Justina Hollanda, Jean-Louis Soares, Dominique Rousset, Agnes Chetty, et al.. HIV Type 1 Diversity in the Seychelles. AIDS Research and Human Retroviruses, Mary Ann Liebert, 2007, 23 (6), pp.761 - 763. ⟨10.1089/aid.2007.0002⟩. ⟨pasteur-01835661⟩

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