Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease

Abstract : BACKGROUND: Abusive alcohol use has well-established health risks including causing liver disease (ALD) characterized by alcoholic steatosis (AS), steatohepatitis (AH), fibrosis, cirrhosis (AC) and hepatocellular carcinoma (HCC). Strikingly, a significant number of individuals who abuse alcohol also use Cannabis, which has seen increased legalization globally. While cannabis has demonstrated anti-inflammatory properties, its combined use with alcohol and the development of liver disease remain unclear. AIM: The aim of this study was to determine the effects of cannabis use on the incidence of liver disease in individuals who abuse alcohol. METHODS: We analysed the 2014 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (NIS) discharge records of patients 18 years and older, who had a past or current history of abusive alcohol use (n = 319 514). Using the International Classification of Disease, Ninth Edition codes, we studied the four distinct phases of progressive ALD with respect to three cannabis exposure groups: non-cannabis users (90.39%), non-dependent cannabis users (8.26%) and dependent cannabis users (1.36%). We accounted for the complex survey sampling methodology and estimated the adjusted odds ratio (AOR) for developing AS, AH, AC and HCC with respect to cannabis use (SAS 9.4). RESULTS: Our study revealed that among alcohol users, individuals who additionally use cannabis (dependent and non-dependent cannabis use) showed significantly lower odds of developing AS, AH, AC and HCC (AOR: 0.55 [0.48-0.64], 0.57 [0.53-0.61], 0.45 [0.43-0.48] and 0.62 [0.51-0.76]). Furthermore, dependent users had significantly lower odds than non-dependent users for developing liver disease. CONCLUSIONS: Our findings suggest that cannabis use is associated with a reduced incidence of liver disease in alcoholics.
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Contributor : Michel Courcelles <>
Submitted on : Monday, August 6, 2018 - 8:52:01 PM
Last modification on : Wednesday, August 14, 2019 - 11:38:04 AM

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Adeyinka Adejumo, Tokunbo Ajayi, Oluwole Adegbala, Kelechi Adejumo, Samson Alliu, et al.. Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease. Liver International, Wiley-Blackwell, 2018, 38 (8), pp.1475 - 1486. ⟨10.1111/liv.13696⟩. ⟨pasteur-01854633⟩

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