The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer

Abstract : Gap junction transmembrane channels allow the transfer of small molecules between the cytoplasm of adjacent cells. They are formed by proteins named connexins (Cxs) that have long been considered as a tumor suppressor. This widespread view has been challenged by recent studies suggesting that the role of Connexin 43 (Cx43) in cancer is tissue- and stage-specific and can even promote tumor progression. High throughput profiling of invasive breast cancer has allowed for the construction of subtyping schemes that partition patients into at least four distinct intrinsic subtypes. This study characterizes Cx43 expression during cancer progression with each of the tumor subtypes using a compendium of publicly available gene expression data. In particular, we show that Cx43 expression depends greatly on intrinsic subtype. Tumor grade also co-varies with patient subtype, resulting in Cx43 co-expression with grade in a subtype-dependent manner. Better survival was associated with a high expression of Cx43 in unstratified and luminal tumors but with a low expression in Her2e subtype. A better understanding of Cx43 regulation in a subtype-dependent manner is needed to clarify the context in which Cx43 is associated with tumor suppression or cancer progression.
Document type :
Journal articles
Complete list of metadatas

Cited literature [63 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01855825
Contributor : Michel Courcelles <>
Submitted on : Wednesday, August 8, 2018 - 3:38:54 PM
Last modification on : Monday, December 10, 2018 - 5:00:05 PM
Long-term archiving on : Friday, November 9, 2018 - 1:38:00 PM

File

ijms-19-00693.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Mélanie Busby, Michael Hallett, Isabelle Plante. The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer. International Journal of Molecular Sciences, MDPI, 2018, 19 (3), pp.E693. ⟨10.3390/ijms19030693⟩. ⟨pasteur-01855825⟩

Share

Metrics

Record views

11

Files downloads

24