Frontline Science: Wnt/β-catenin pathway promotes early engraftment of fetal hematopoietic stem/progenitor cells

Edward Kwarteng; Roxann Hétu-Arbour; Krista Heinonen

Frontline Science: Wnt/β-catenin pathway promotes early engraftment of fetal hematopoietic stem/progenitor cells

Edward Kwarteng ¹ Roxann Hétu-Arbour ¹ Krista Heinonen ^{1, *}

* Corresponding author

Abstract : The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypothesized that proliferating fetal HSPCs would be more dependent on canonical β-catenin-dependent Wnt signaling when compared to quiescent adult bone marrow HSPCs. We have compared here Wnt signaling activities in murine fetal and adult HSPCs and demonstrate a shift from Wnt/β-catenin-dependent signaling in fetal liver HSPCs to more predominantly noncanonical Wnt/polarity signaling in adult HSPCs. β-Catenin was selectively required for fetal HSPC competitiveness shortly after transplant, and protected cells from oxidative stress. Our results emphasize the complexity of Wnt signaling dynamics in HSPC maintenance and function.

Keywords : hematopoietic stem cells Wnt signaling beta-catenin bone marrow development fetal liver

Document type :

Journal articles

Domain :

Sciences of the Universe [physics]

Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-01855961
Contributor : Michel Courcelles <>
Submitted on : Wednesday, August 8, 2018 - 10:07:23 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM

Frontline Science: Wnt/β-catenin pathway promotes early engraftment of fetal hematopoietic stem/progenitor cells

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Frontline Science: Wnt/β-catenin pathway promotes early engraftment of fetal hematopoietic stem/progenitor cells

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