Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata

Messika Revel; Michel Fournier; Pierre Yves Robidoux

Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata

Messika Revel ^{1, 2, *} Michel Fournier ² Pierre Yves Robidoux ^{3, 2}

* Corresponding author

1 NRC - National Research Council of Canada

2 INRS-IAF - Institut Armand Frappier

3 AGAT Laboratories

Abstract : Potential immunotoxicity and genotoxicity of as-produced and purified single walled carbon nanotubes (SWCNT, 500 μg L-¹) with or without cadmium (20 μg L-¹) was investigated in hemocytes of the freshwater mussel, Elliptio complanata. Our results showed a decrease in hemocyte viability after 3, and 8 days of exposure and an increase of hemocyte phagocytic efficiency for organisms exposed to Cd. No modification of the cyclo-oxygenase (COX) activity was measured. An increase in DNA damage was measured after 1 day of exposure to Cd and a potentiating effect of combined exposures was observed.

Keywords : SWCNT Mussels Cadmium DNA damage Interaction

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://hal-riip.archives-ouvertes.fr/pasteur-01856092
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Submitted on : Thursday, August 9, 2018 - 4:09:04 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM

Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata

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Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata

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