Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata

Messika Revel (1, 2) , Michel Fournier (2) , Pierre Yves Robidoux (3, 2)

1 NRC - National Research Council of Canada
2 INRS-IAF - Institut Armand Frappier
3 AGAT Laboratories

Potential immunotoxicity and genotoxicity of as-produced and purified single walled carbon nanotubes (SWCNT, 500 μg L-¹) with or without cadmium (20 μg L-¹) was investigated in hemocytes of the freshwater mussel, Elliptio complanata. Our results showed a decrease in hemocyte viability after 3, and 8 days of exposure and an increase of hemocyte phagocytic efficiency for organisms exposed to Cd. No modification of the cyclo-oxygenase (COX) activity was measured. An increase in DNA damage was measured after 1 day of exposure to Cd and a potentiating effect of combined exposures was observed.

Keywords: Cadmium; DNA damage; Interaction; Mussels; SWCNT

Domains: Life Sciences [q-bio]

Messika Revel, Michel Fournier, Pierre Yves Robidoux. Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata. Environmental Toxicology and Pharmacology, 2018, 62, pp.177 - 180. ⟨10.1016/j.etap.2018.07.008⟩. ⟨pasteur-01856092⟩