The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I)

Abstract : New drugs are needed to treat flatworm infections that cause severe human diseases such as schistosomiasis. The unique flatworm enzyme thioredoxin glutathione reductase (TGR), structurally different from the human enzyme, is a key drug target. Structural studies of the flatworm Echinococcus granulosus TGR, free and complexed with AuI-MPO, a novel gold inhibitor, together with inhibition assays were performed.
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Submitted on : Wednesday, September 26, 2018 - 8:52:40 PM
Last modification on : Friday, February 22, 2019 - 11:16:45 AM

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Gustavo Salinas, Wei Gao, Yang Wang, Mariana Bonilla, Long Yu, et al.. The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). Antioxidants and Redox Signaling, Mary Ann Liebert, 2017, 27 (18), pp.1491 - 1504. ⟨10.1089/ars.2016.6816⟩. ⟨pasteur-01882359⟩

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