Skip to Main content Skip to Navigation
Journal articles

The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I)

Abstract : New drugs are needed to treat flatworm infections that cause severe human diseases such as schistosomiasis. The unique flatworm enzyme thioredoxin glutathione reductase (TGR), structurally different from the human enzyme, is a key drug target. Structural studies of the flatworm Echinococcus granulosus TGR, free and complexed with AuI-MPO, a novel gold inhibitor, together with inhibition assays were performed.
Complete list of metadata

https://hal-riip.archives-ouvertes.fr/pasteur-01882359
Contributor : Mariella Botta Connect in order to contact the contributor
Submitted on : Wednesday, September 26, 2018 - 8:52:40 PM
Last modification on : Tuesday, January 18, 2022 - 2:50:08 PM

Links full text

Identifiers

Collections

Citation

Gustavo Salinas, Wei Gao, Yang Wang, Mariana Bonilla, Long Yu, et al.. The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). Antioxidants and Redox Signaling, Mary Ann Liebert, 2017, 27 (18), pp.1491 - 1504. ⟨10.1089/ars.2016.6816⟩. ⟨pasteur-01882359⟩

Share

Metrics

Les métriques sont temporairement indisponibles