Estimating sources and sinks of malaria parasites in Madagascar

Abstract : In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals.
Document type :
Journal articles
Complete list of metadatas

Cited literature [7 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01911242
Contributor : Volatiana Manohisoa Randriamanantsoa <>
Submitted on : Friday, November 2, 2018 - 3:25:04 PM
Last modification on : Friday, May 17, 2019 - 1:19:24 AM
Long-term archiving on : Sunday, February 3, 2019 - 12:51:13 PM

File

Estimating sources and sinks o...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Felana Ihantamalala, Vincent Herbreteau, Feno Rakotoarimanana, Jean Rakotondramanga, Simon Cauchemez, et al.. Estimating sources and sinks of malaria parasites in Madagascar. Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3897. ⟨10.1038/s41467-018-06290-2⟩. ⟨pasteur-01911242⟩

Share

Metrics

Record views

80

Files downloads

56