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Evaluating new rabies post-exposure prophylaxis (PEP) regimens or vaccines

Abstract : The development of human rabies vaccines has evolved dramatically from the first crude nerve tissue vaccine produced then administered in the presence of Louis Pasteur in 1885. New cell culture technology has enabled highly potent and well-tolerated rabies vaccines to be produced that have reduced the volume and number of doses required to save human lives after exposure. However, these highly potent vaccines are still unaffordable to many patients living at risk of exposure on a daily basis. The cost of post-exposure prophylaxis (PEP) is not only related to the direct cost of rabies biologicals and equipment but is also associated with indirect costs that patients incur as a result of travel, loss of work time (income loss), and accommodation over the period of time that a PEP regimen requires to be completed. This paper summarizes the particular criteria that the SAGE Working Group and WHO personnel reviewed as part of the evaluation process for recommending the new one-week intradermal vaccination regimen (2-2-2-0-0) for rabies post-exposure prophylaxis. These criteria included: Cost-effectiveness; evaluation of number of doses; seroconversion after vaccination; efficacy; safety; and patient follow-up.
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Submitted on : Monday, December 3, 2018 - 9:52:06 PM
Last modification on : Thursday, February 7, 2019 - 3:23:01 PM

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Arnaud Tarantola, Mathurin Cyrille Tejiokem, Deborah Briggs. Evaluating new rabies post-exposure prophylaxis (PEP) regimens or vaccines. Vaccine, Elsevier, 2018, ⟨10.1016/j.vaccine.2018.10.103⟩. ⟨pasteur-01943559⟩

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