Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia - Archive ouverte HAL Access content directly
Journal Articles Vaccine Year : 2019

Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia

Abstract

This cross-sectional study aimed to assess pertussis seroprevalence among healthy healthcare workers (HCW) of the Children's Hospital of Tunis, Tunisia. During the study period, 236 blood samples were obtained to determine HCW exposure to pertussis. Concentrations of immunoglobulin G (IgG) to pertussis toxin (PT) were measured using a commercial enzyme-linked immunosorbent assay. Cut-offs values used were 40 and 100 IU/ml, respectively indicative of an infection within the last year and a current/recent infection. Overall, seropositivity rate was 11.4% (95% CI 7.4-15.5) and 2.5% (95% CI 0.5-4.6) of ELISA results were indicative of a current infection. Seroprevalence was significantly most important in nurses (p = 0.03) and in participants aged 21-31y (p = 0.009). Our study confirmed that pertussis is circulating in hospital settings and affecting Tunisian HCW, in close contact with infants. Therefore, a booster dose of acellular pertussis vaccine needs to be considered.
Not file

Dates and versions

pasteur-01946455 , version 1 (06-12-2018)

Identifiers

Cite

Ikram Ben Fraj, Hanen Smaoui, Maroua Zghal, Orjouane Sassi, Nicole Guiso, et al.. Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia. Vaccine, 2019, 37 (1), pp.109-112. ⟨10.1016/j.vaccine.2018.11.023⟩. ⟨pasteur-01946455⟩
27 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More