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Solar insolation in springtime influences age of onset of bipolar I disorder

M. Bauer 1, * T. Glenn 2 M. Alda 3 M. Aleksandrovich 4 O. Andreassen 5 E. Angelopoulos 6 R. Ardau 7 Y. Ayhan 8 C. Baethge 9 R. Bharathram 10 R. Bauer 1 T. Baune 11 C. Becerra-Palars 12 F. Bellivier 13 R. Belmaker 14 M. Berk 15, 16 Y. Bersudsky 14 Ş. Bicakci 17 H. Birabwa-Oketcho 18 T. Bjella 5 L. Bossini 19 J. Cabrera 20 E. Cheung 21 M. del Zompo 7 S. Dodd 16, 22 M. Donix 1 B. Etain 13 A. Fagiolini 7 K. Fountoulakis 23 M. Frye 24 A. Gonzalez-Pinto 25 F. Gottlieb 26 P. Grof 27 H. Harima 28, 29 C. Henry 30, 31 T. Isometsä 32, 33 S. Janno 34 F. Kapczinski 35 M. Kardell 36 S. Khaldi S. Kliwicki 37 B. König 38 T. Kot 39 R. Krogh 40 M. Kunz 35 B. Lafer 41 M. Landén 36, 42 E. Larsen 40 U. Lewitzka 1 R. Licht 40, 43 C. Lopez-Jaramillo 44 G. Macqueen 45 M. Manchia 7 W. Marsh 46 M. Martinez-Cengotitabengoa 25 K. Melle 5 F. Meza-Urzúa 12 M. Yee Ming 47 S. Monteith 48 G. Morken 49, 50 E. Mosca 7 R. Munoz 51 S. Mythri 52 F. Nacef 53 R. Nadella 10 F. Nery 41 E. Nielsen 40, 43 C. O'Donovan 3 A. Omrani Y. Osher 14 H. Østermark Sørensen 40 U. Ouali 54 Y. Pica Ruiz 55 M. Pilhatsch 1 M. Pinna 56 R. da Ponte 35 D. Quiroz 57 R. Ramesar 58 N. Rasgon 59 M. Reddy 52 A. Reif 60 P. Ritter 1 J. Rybakowski 37 K. Sagduyu 61 M. Scippa 62 E. Severus 1 C. Simhandl 38 J. Stein 63 S. Strejilevich 64 M. Subramaniam 47 H. Sulaiman 65 K. Suominen H. Tagata 29 Y. Tatebayashi 66 L. Tondo 67 C. Torrent 68 E. Vaaler 49, 50 J. Veeh 69, 70 E. Vieta 68 B. Viswanath 10 M. Yoldi-Negrete 12, 71 M. Zetin 72 Y. Zgueb 54 C. Whybrow 73
* Corresponding author
5 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
UiO - University of Oslo, Haukeland University Hospital, Oslo University Hospital [Oslo]
Abstract : OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
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Submitted on : Thursday, December 20, 2018 - 12:51:47 PM
Last modification on : Friday, October 23, 2020 - 6:48:04 PM

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M. Bauer, T. Glenn, M. Alda, M. Aleksandrovich, O. Andreassen, et al.. Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica, Wiley, 2017, 136 (6), pp.571-582. ⟨10.1111/acps.12772⟩. ⟨pasteur-01962050⟩

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