Protective effect of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced injury in rat gastric mucosa - Archive ouverte HAL Access content directly
Journal Articles Pathophysiology Year : 2018

Protective effect of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced injury in rat gastric mucosa

(1, 2) , (2) , (3) , (1) , (2) , (1, 2)
1
2
3

Abstract

BACKGROUND: Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile (Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. METHODS: Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b.w.), EtOH+famotidine (FAM) and EtOH+ascorbic acid (AA). Gastric ulceration was induced by EtOH (4g/kg, b.w. p.o.). RESULTS: Firsly, we found that acute alcohol administration leads to mark macroscopic and histologic changes in gastric mucosa. EtOH also induced lipoperoxidation (486.99%), thiol (-SH) groups decrease (40.98%) as well as antioxidant enzyme activity depletion such as superoxide dismutase (SOD) (49.05%), catalase (CAT) (46.80%) and glutathione peroxidase (GPx) (38.20%). Our results also demonstrated that alcohol intoxication increased tissue and plasmatic hydrogen peroxide, calcium and free iron levels. More importantly, CDE reversed all macroscopic, histologic and biochemical changes induced by EtOH administration. CONCLUSION: A potential gastropreotective effect of CDE against EtOH-induced ulcer and oxidative stress might be partially to its antioxidant properties as well as to various gastric mucosal defense mechanisms, including protection of gastric sulfhydryls and its opposite effect on some intracellular mediators such as free iron, hydrogen peroxide and calcium.
Not file

Dates and versions

pasteur-01965241 , version 1 (25-12-2018)

Identifiers

Cite

Mohamed-Amine Jabri, Nadhem Aissani, Haifa Tounsi, Mohsen Sakly, Lamjed Marzouki, et al.. Protective effect of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced injury in rat gastric mucosa. Pathophysiology, 2018, 24 (1), pp.1-8. ⟨10.1016/j.pathophys.2016.11.001⟩. ⟨pasteur-01965241⟩

Collections

RIIP RIIP_TUNIS
38 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More