Novel variants of mitochondrial DNA associated with Type 2 diabetes mellitus in Moroccan population

Hicham Charoute (1) , Rym Kefi (2, 3) , Safaa Bounaceur (1) , Houda Benrahma (1) , Ahmed Reguig (1) , Mostafa Kandil (4) , Hassan Rouba (1) , Amina Bakhchane (1) , Sonia Abdelhak (3) , Abdelhamid Barakat (1)

1 Laboratoire de Génétique Moléculaire Humaine
2 UTM - Université de Tunis El Manar
3 LR11IPT05 - Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory
4 UCD - Université Chouaib Doukkali

In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 of the mtDNA was sequenced in 108 diabetic patients and 97 controls. Association analyses were performed using Fisher's exact test and multivariate logistic regression. The prevalence of five mtDNA variants (C16187T, C16270T, T16172C, A16293G, and C16320T) was significantly higher in cases than in controls. Among these variants, only C16270T (p = .02) and C16320T (p = .03) remains significant after adjusting by age and gender. We showed that C16270T and C16320T variants were strongly associated with increased risk of T2D in Moroccan patients.

Keywords: Mitochondria; Type 2 diabetes; genetic association; hypervariable segment 1; mitochondrial variant

Domains: Life Sciences [q-bio]; Biochemistry, Molecular Biology

Hicham Charoute, Rym Kefi, Safaa Bounaceur, Houda Benrahma, Ahmed Reguig, et al.. Novel variants of mitochondrial DNA associated with Type 2 diabetes mellitus in Moroccan population. Mitochondrial DNA Part A, 2017, 29 (1), pp.9-13. ⟨10.1080/24701394.2016.1233530⟩. ⟨pasteur-01966344⟩