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Journal articles

Genomic epidemiology of artemisinin resistant malaria

Roberto Amato 1 Olivo Miotto 2 Charles J Woodrow 2 Jacob Almagro-Garcia 3 Ipsita Sinha 2 Susana Campino 1 Daniel Mead 1 Eleanor Drury 1 Mihir Kekre 1 Mandy Sanders 1 Alfred Amambua-Ngwa 4 Chanaki Amaratunga 5 Lucas Amenga-Etego 6 Voahangy Hanitriniaina Andrianaranjaka 7 Tobias Apinjoh 8 Elizabeth Ashley 2 Sarah Auburn 9 Gordon A Awandare 10 Vito Baraka 11 Alyssa Barry 12 Maciej Boni 13 Steffen Borrmann 14 Teun Bousema 15 Oralee Branch 16 Peter C Bull 14 Kesinee Chotivanich 17 David J Conway 4 Alister Craig 18 Nicholas P Day 2 Abdoulaye Djimde 19 Christiane Dolecek 13 Arjen M Dondorp 2 Chris Drakeley 15 Patrick Duffy 5 Diego F Echeverry 20 Thomas G Egwang 21 Rick M Fairhurst 5 Abul Faiz Caterina Fanello 2 Tran Tinh Hien 13 Abraham Hodgson 6 Mallika Imwong 2 Deus Ishengoma 11 Pharath Lim 5 Chanthap Lon 22 Jutta Marfurt 9 Kevin Marsh 14 Mayfong Mayxay 23 Pascal Michon 24 Victor Mobegi 4 Olugbenga A Mokuolu 25 Jacqui Montgomery 26 Ivo Mueller 27 Myat Phone Kyaw 28 Paul N Newton 23 François Nosten 2 Rintis Noviyanti 29 Alexis Nzila 30 Harold Ocholla 31 Abraham Oduro 6 Marie Onyamboko 32 Jean-Bosco Ouédraogo 33 Aung Pyae P Phyo 34 Christopher V Plowe 35 Ric Price 36 Sasithon Pukrittayakamee 37 Milijaona Randrianarivelojosia 7 Pascal Ringwald 38 Lastenia Ruiz 39 David Saunders 22 Alex Shayo 40 Peter Siba 41 Shannon Takala-Harrison 35 Thuy-Nhien N Thanh 36 Vandana Thathy 14 Federica Verra 15 Jason Wendler 3 Nicholas White 42 Htut ye 28 Victoria Cornelius 3 Rachel Giacomantonio 3 Dawn Muddyman 1 Christa Henrichs 3 Cinzia Malangone 1 Dushyanth Jyothi 1 Richard Pearson 3 Julian Rayner 1 Gilean Mcvean 3 Kirk Rockett 3 Alistair Miles 3 Paul Vauterin 3 Ben Jeffery 3 Magnus Manske 1 Jim Stalker 1 Bronwyn Macinnis 1 Dominic Kwiatkowski 1 
20 Department of Entomology [West Lafayette]
Purdue University [West Lafayette]
26 Department of Entomology [University Park]
Penn State - Pennsylvania State University
31 MLW - Malawi Liverpool Wellcome Trust Clinical Research Programme
LSTM - Liverpool School of Tropical Medicine, University of Liverpool, Wellcome Trust, University of Malawi
Abstract : The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelch13 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.
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Submitted on : Monday, January 7, 2019 - 2:09:38 PM
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Roberto Amato, Olivo Miotto, Charles J Woodrow, Jacob Almagro-Garcia, Ipsita Sinha, et al.. Genomic epidemiology of artemisinin resistant malaria. eLife, eLife Sciences Publication, 2016, 48 (8), pp.959-964. ⟨10.7554/eLife.08714⟩. ⟨pasteur-01971950⟩



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