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Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.

Abstract : Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to GM1 or GD1a gangliosides were detected by enzyme linked immunosorbent-assay (ELISA) in plasmas from ANPA patients but not in controls. These data suggest that antibodies to GM1 and GD1a gangliosides may play a pathogenic role in the demyelinating and/or inflammatory processes characteristic of rabies vaccine-induced acute neurologic complications.
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Submitted on : Friday, January 18, 2019 - 10:27:45 AM
Last modification on : Tuesday, July 16, 2019 - 5:16:57 PM

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Dhafer Laouini, M.F. Kennou, S. Khoufi, Koussay Dellagi. Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.. Journal of Neuroimmunology, Elsevier, 1998, 91 (1-2), pp.63-72. ⟨10.1016/S0165-5728(98)00153-2⟩. ⟨pasteur-01985581⟩

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