Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

João Perdigão 1, * Carla Silva 1 Jaciara Diniz 2 Catarina Pereira 1 Diana Machado 3 Jorge Ramos 3 Hugo Silva 1 Fernanda Abilleira 2 Clarice Brum 2 Ana Reis 2 Maíra Macedo 2 João Scaini 2 Anna Silva 2 Leonardo Esteves 4 Rita Macedo 5 Fernando Maltez 6 Sofia Clemente 7 Elizabeth Coelho 8 Sofia Viegas 8 Paulo Rabna 9 Amabélia Rodrigues 9 Nuno Taveira 10, 1 Luísa Jordao 5 Afrânio Kritski 11 José Lapa E Silva 12 Igor Mokrousov 13 David Couvin 14 Nalin Rastogi 14 Isabel Couto 3 Arnab Pain 15 Ruth Mcnerney 16 Taane Clark 17 Andrea von Groll 2 Elis Dalla-Costa 4 Maria Rossetti 4 Pedro E.A. Silva 18 Miguel Viveiros 3 Isabel Portugal 1, *
Abstract : Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analysed the largest CPLP M. tuberculosis molecular and drug susceptibility dataset, comprised by a total of 1447 clinical isolates, including 423 multidrug-resistant isolates, from five CPLP countries. The data herein presented reinforces Latin American and Mediterranean (LAM) strains as the hallmark of M. tuberculosis popu-lational structure in the CPLP coupled with country-specific differential prevalence of minor clades. Moreover, using high-resolution typing by 24-loci MIRU-VNTR, six cross-border genetic clusters were detected, thus supporting recent clonal expansion across the Lusophone space. To make this data available to the scientific community and public health authorities we developed CPLP-TB (available at http://cplp-tb.ff.ulisboa.pt), an online database coupled with web-based tools for exploratory data analysis. As a public health tool, it is expected to contribute to improved knowledge on the M. tuberculosis population structure and strain circulation within the CPLP, thus supporting the risk assessment of strain-specific trends.
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João Perdigão, Carla Silva, Jaciara Diniz, Catarina Pereira, Diana Machado, et al.. Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries. Infection, Genetics and Evolution, Elsevier, 2019, Molecular aspects of mycobacteril infections, 72, pp.44-58. ⟨10.1016/j.meegid.2018.03.011⟩. ⟨pasteur-01986661⟩

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