M. O. Agaphonov, N. V. Romanova, P. M. Trushkina, V. N. Smirnov, and M. D. Ter-avanesyan, Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum, BMC Mol Biol, vol.3, pp.15-23, 2002.

M. Ahmad, M. Hirz, H. Pichler, and H. Schhwab, Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production, Appl Microbiol Biotechnol, vol.12, pp.5301-5317, 2014.

A. Anilionis, W. H. Wunner, C. , and P. J. , Structure of the glycoprotein gene in rabies virus, Nature, vol.294, pp.275-278, 1981.

M. P. Ashe and R. M. Bill, Mapping the yeast host cell response to recombinant membrane protein production relieving the biological bottlenecks, Biotechnol J, vol.6, pp.707-714, 2011.

J. Bai, D. J. Swartz, I. Protasevich, C. Brouillette, P. Harrell et al., A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris, PlosOne, vol.6, pp.1-15, 2011.

K. Baumann, N. Adelantado, C. Lang, D. Mattanovich, and P. Ferrer, Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris, Microb Cell Fact, vol.10, pp.93-108, 2011.

S. Ben-azoun, M. Ben-zakour, S. Sghaeir, and H. Kallel, Expression of rabies virus glycoprotein in the methylotrophic yeast Pichia pastoris, Biotechnol Appl Biochem, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01446906

J. L. Cereghino and J. M. Cregg, Heterologous protein expression in the methylotrophic yeast Pichia pastoris, FEMS Microbiol Rev, vol.24, pp.45-66, 2000.

C. N. Chang, M. Matteucci, J. Perry, J. J. Wulf, C. Y. Chen et al., Saccharomyces cerevisiae secretes and correctly processes human interferon hybrid proteins containing yeast invertase signal peptides, Mol Cell Biol, vol.6, pp.1812-1819, 1986.

J. H. Cox, B. Dietzschold, and L. G. Schneider, Rabies virus glycoprotein. II. Biological and serological characterization, Infect Immun, vol.16, pp.754-759, 1977.

L. M. Damasceno, K. A. Anderson, G. Ritter, J. M. Cregg, L. J. Old et al., Cooverexpression of chaperones for enhanced secretion of a single-chain antibody fragment in Pichia pastoris, Appl Microbiol Biotechnol, vol.74, pp.381-389, 2007.

L. M. Damasceno, C. J. Huang, and C. A. Batt, Protein secretion in Pichia pastoris and advances in protein production, Appl Microbiol Biotechnol, vol.93, pp.31-39, 2012.

M. Delic, C. Rebnegger, F. Wanka, V. Puxbaum, C. Troyer et al., Oxidative protein folding and unfolded protein response elicit differing redox regulation in endoplasmic reticulum and cytosol of yeast, Free Radic Biol Med, vol.52, pp.2000-2012, 2012.

M. Delic, A. B. Graf, G. Koellensperger, C. Haberhauertroyer, S. Hann et al., Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion, Microb Cell, vol.1, pp.376-386, 2014.

B. Gasser, R. Prielhofer, H. Marx, M. Maurer, J. Nocon et al., Pichia pastoris-protein production host and model organism for biomedical research, Future Microbiol, vol.8, pp.191-208, 2013.

Y. Gaudin, R. Ruigrok, C. Tuffereau, M. Knossow, F. et al., Rabies glycoprotein is a trimer. Virology, vol.187, pp.627-632, 1992.

A. Ghosalkar, V. Sahai, and A. Srivastava, Secretory expression of interferon-alpha 2b in recombinant Pichia pastoris using three different secretion signals, Protein Exp Purif, vol.60, pp.103-109, 2008.

Y. Hashimoto, N. Koyabu, and T. Imoto, Effects of signal sequences on the secretion of hen lysozyme by yeast: construction of four secretion cassette vectors, Protein Eng, vol.11, pp.75-77, 1998.

H. Heimo, K. Palmu, and I. Suominen, Expression in Pichia pastoris and purification of Aspergillus awamori glucoamylasecatalytic domain, Protein Exp Purif, vol.10, pp.70-79, 1997.

A. Helenius, T. Marquardt, and I. Braakman, The endoplasmic reticulum as a protein-folding compartment, Trends Cell Biol, vol.2, pp.227-231, 1992.

A. R. Hesketh, J. I. Castrillo, T. Sawyer, D. B. Archer, and S. G. Oliver, Investigating the physiological response of Pichia (Komagataella) pastoris GS115 to the heterologous expression of misfolded proteins using chemostat cultures, Appl Microbiol Biotechnol, vol.97, pp.9747-9762, 2013.

H. Hohenblum, B. Gasser, M. Maurer, N. Borth, and D. Mattanovich, Effects of gene dosage, promoters, and substrates on unfolded proteinstress of recombinant Pichia pastoris, Biotechnol Bioeng, vol.85, pp.367-375, 2004.

J. Hoseki, R. Ushioda, and K. Nagata, Mechanism and components of endoplasmic reticulum-associated degradation, J Biochem, vol.147, pp.19-25, 2010.

N. Ide, T. Masuda, K. , and N. , Effects of pre-and pro-sequence of thaumatin on the secretion by Pichia pastoris, Biochem Biophys Res Commun, vol.363, pp.708-714, 2007.

M. Inan, M. Aryasomayajula, J. D. Sinha, and M. M. Meagher, Enhancement of protein secretion in Pichia pastoris by overexpression of protein disulfide isomerase, Biotechnol Bioeng, vol.93, pp.771-778, 2006.

K. J. Kauffman, E. M. Pridgen, F. J. Doyle, P. S. Dhurjati, R. et al., Decreased protein expression and intermittent recoveries in BiP levels result from cellular stress during heterologous protein expression in Saccharomyces cerevisiae, Biotechnol Prog, vol.18, pp.942-950, 2002.

J. A. Killian, A. M. De-jong, J. Bijvelt, A. J. Verklei, and B. De-kruijfff, Induction of non-bilayer lipid structures by functional signal peptides, EMBO J, vol.9, pp.815-819, 1990.

N. Koganesawa, T. Aizawa, K. Masaki, A. Matsuura, T. Nimori et al., Construction of an expression system of insect lysozyme lacking thermal stability: the effect of selection of signal sequence on level of expression in the Pichia pastoris expression system, Prot Eng, vol.14, pp.705-710, 2001.

K. Kohno, Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals, J Biochem, vol.147, pp.27-33, 2010.

C. P. Kurtzman, Biotechnological strains of Komagataella (Pichia) pastoris are Komagataella phaffii as determined from multigene sequence analysis, J Ind Microbio lBiotechnol, vol.36, pp.1435-1438, 2009.

M. Leonardo, C. Damasceno, and C. Batt, Protein secretion in Pichia pastoris and advances in protein production, Appl Microbiol Biotechnol, vol.93, pp.31-39, 2012.

P. Li, A. Anumanthan, X. Gao, K. Ilangovan, V. Suzara et al., Expression of recombinant proteins in Pichia pastoris, Appl Biochem Biotechnol, vol.142, pp.105-124, 2007.

X. Li, J. Luo, S. Wang, Y. Shen, Y. Qiu et al., Engineering, expression, and immune-characterization of recombinant protein comprising multi-neutralization sites of rabies virus glycoprotein, Prot Exp Purif, vol.70, p.183, 2010.

X. Q. Lin, S. L. Liang, S. Y. Han, S. P. Zheng, Y. R. Ye et al., Quantitative iTRAQ LC-MS/MS proteomic reveals the cellular response to heterologous protein overexpression and the regulation of HAC1 in Pichia pastoris, J Proteomics, vol.91, pp.58-72, 2013.

T. Lodi, B. Neglia, and C. Donnini, Secretion of human serumalbumin by Kluyveromyces lactis overexpressing KlPDI1 and KlERO1, Appl Environ Microbiol, vol.71, pp.4359-4363, 2005.
DOI : 10.1128/aem.71.8.4359-4363.2005
URL : https://aem.asm.org/content/71/8/4359.full.pdf

H. L?-unsdorf, C. Gurramkonda, A. Adnan, N. Khanna, R. et al., Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surfaceantigen, Microb Cell Fact, vol.10, pp.48-58, 2011.

C. Ngiam, D. J. Jeenes, P. J. Punt, C. A. Hondel, and D. B. Archer, Characterisation of a foldase, protein disulphide isomerase A, in the proteinsecretory pathway of Aspergillus Niger, Appl Environ Microbiol, vol.66, pp.775-782, 2000.

K. Norden, M. Agemark, J. Danielson, E. Alexandresson, P. Kjelbom et al., Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris, BMC Biotechnol, vol.11, pp.47-59, 2011.

E. Paifer, E. Margolles, J. Cremata, R. Montesino, L. Herrera et al., Efficient expression and secretion of recombinant alpha amylase in Pichia pastoris using two different signal sequences, Yeast, vol.10, pp.1415-1419, 1994.

W. E. Payne, P. M. Gannon, and C. A. Kaiser, An inducible acidphosphatase from the yeast Pichia pastoris: characterization of the gene and its product, Gene, vol.163, pp.19-26, 1995.

M. Pfaffl, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Res, vol.29, pp.2003-2007, 2005.

T. A. Rapoport, Transport of proteins across the endoplasmic reticulum membrane, Science, vol.258, pp.931-936, 1992.

P. A. Romero, M. Lussier, A. M. Sdicu, H. Bussey, and A. Herscovics, Ktr1p is an a-1, 2-mannosyltransferase of Saccharomyces cerevisiae: comparison of the enzymatic properties of soluble recombinant Ktr1p and Kre2p/Mnt1p produced in Pichia pastoris, Biochem J, vol.321, pp.289-295, 1997.

S. Shen, G. Sulter, C. , and J. , A strong nitrogen source-regulated promoter for controlled expression of foreign genes in the yeast Pichia pastoris, Gene, vol.216, pp.93-102, 1998.

Q. Shen, W. Ming, W. Hai-bin, N. Hua, and C. Shu-qing, The effect of gene copy number and co-expression of chaperone on production of albumin fusion proteins in Pichia pastoris, Appl Gen Mol Biotechnol, vol.96, pp.763-772, 2012.

J. S. Smith, P. A. Yager, and G. M. Baer, A rapid tissue culture test for determining rabies neutralizing antibody, Laboratory Techniques in Rabies, pp.354-357, 1973.

K. Sreekrishna, R. G. Brankamp, K. E. Kropp, D. T. Blankenship, J. T. Tsay et al., Strategies for optimal synthesis and secretion of heterologous proteins in the methylotrophic yeast Pichia pastoris, Gene, vol.190, pp.55-62, 1997.

M. B. Toledano, A. Delaunay-moisan, C. E. Outten, and A. Igbaria, Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast, Antioxid Redox Signal, vol.18, pp.1699-1711, 2013.

B. P. Tu, S. C. Ho-schleyer, K. J. Traves, and J. S. Weissman, Biochemical basis of oxidative protein folding in the endoplasmic reticulum, Science, vol.290, pp.1571-1574, 2000.

R. Vad, E. Nafstad, L. Dahl, and O. Gabrielsen, Engineering of a Pichia pastoris expression system for secretion of high amounts of intact human parathyroid hormone, J Biotechnol, vol.116, pp.251-260, 2005.

A. L. Vanz, H. Lunsdorf, A. Adnan, M. Nimtz, C. Gurramkonda et al., Physiological response of Pichia pastoris GS115 to methanolinduced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes, Microb Cell Factories, vol.11, pp.103-113, 2012.

A. L. Vanz, M. Nimtz, R. , and U. , Decrease of UPR-and ERAD-related proteins in Pichia pastoris during methanol-induced secretory insulin precursor production in controlled fed-batch cultures, Microb Cell Factories, vol.13, pp.23-33, 2014.

G. Von-heijne, The signal peptide, J Memb Biol, vol.115, pp.195-201, 1990.

D. Vujaklija, W. Schro, A. , and M. , A novel streptomycete lipase: cloning, sequencing and high-level expression of the Streptomyces rimosus GDS(L)-lipase gene, Arch Microbiol, vol.178, pp.124-130, 2002.

P. J. Walker and K. Kongsuwan, Deduced structural model for animal rhabdovirus glycoproteins, J Gen Virol, vol.80, pp.1211-1220, 1999.
DOI : 10.1099/0022-1317-80-5-1211
URL : http://jgv.microbiologyresearch.org/deliver/fulltext/jgv/80/5/0801211a.pdf?itemId=/content/journal/jgv/10.1099/0022-1317-80-5-1211&mimeType=pdf&isFastTrackArticle=

G. Whyteside, R. M. Nor, M. J. Alcocer, and D. B. Archer, Activation of the unfolded protein response in Pichia pastoris requires splicing of a HAC1 mRNA intron and retention of the C-terminal tail of Hac1p, FEBS Lett, vol.585, pp.1037-1041, 2011.

J. K. Yang and L. Y. Liu, Codon optimization through a two-step gene synthesis leads to a high-level expression of Aspergillus niger lip 2 gene in Pichia pastoris, J Mol Cat B Enzymatic, vol.63, pp.164-169, 2010.

S. Yang, Y. Kuang, H. Li, Y. Liu, X. Hui et al., Enhanced production of recombinant secretory proteins in Pichia pastoris by optimizing Kex2 P1site, PLoS ONE, vol.8, pp.75347-75358, 2013.

T. Yano, E. Takigami, H. Yurimoto, and Y. Sakai, Yap1-regulated glutathione redox system curtails accumulation of formaldehyde and reactive oxygen species in methanol metabolism of Pichia pastoris, Eukaryot Cell, vol.8, pp.540-549, 2009.

X. Yu, L. Wang, and Y. Xu, Rhizopuschinensis lipase: gene cloning, expression in Pichia pastoris andproperties, J Mol Cat B Enzymatic, vol.57, pp.304-311, 2009.

M. Yu, S. Wen, T. , and T. , Enhancing production of Yarrowia lipolytica lipase Lip2 in Pichia pastoris, Eng Life Sci, vol.10, pp.458-464, 2010.

H. Zhao, Q. He, C. Xue, B. Sun, X. Yao et al., Secretory expression of glycosylated and aglycosylated mutein of onconase from Pichia pastoris using different secretion signals and their purification and characterization, FEMS Yeast Res, vol.9, pp.591-599, 2009.

T. Zhu, M. Guo, Z. Tang, M. Zhang, Y. Zhuang et al., Efficient generation of multi-copy strains for optimizing secretory expression of porcine insulin precursor in yeast Pichia pastoris, J Appl Microbiol, vol.107, pp.954-963, 2009.

T. Zhu, M. Guo, Y. Zhuang, J. Chu, and S. Zhang, Understanding the effect of foreign gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes, Appl Microbiol Biotechnol, vol.89, pp.1127-1135, 2011.