Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity, J. Immunol, vol.183, pp.718-731, 2009. ,
Recall of longlived immunity to Mycobacterium tuberculosis infection in mice, J. Immunol, vol.154, pp.3359-3372, 1995. ,
Macrophage polarization in bacterial infections, J. Immunol, vol.181, pp.3733-3739, 2008. ,
Early secreted antigenic target of 6kDa (ESAT-6) protein of Mycobacterium tuberculosis induces interleukin-8 (IL-8) expression in lung epithelial cells via protein kinase signaling and reactive oxygen species, J. Biol. Chem, vol.288, pp.25500-25511, 2013. ,
Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype, Trends Immunol, vol.32, pp.241-247, 2011. ,
Host evasion and exploitation schemes of Mycobacterium tuberculosis, Cell, vol.159, pp.1497-1509, 2014. ,
Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis, FEBS Lett, vol.584, pp.2445-2454, 2010. ,
The role of the granuloma in expansion and dissemination of early tuberculous infection, Cell, vol.136, pp.37-49, 2009. ,
Modeling the immune rheostat of macrophages in the lung in response to infection, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.11246-11251, 2009. ,
Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV, Cell. Microbiol, vol.6, pp.999-1009, 2004. ,
DOI : 10.1111/j.1462-5822.2004.00449.x
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1462-5822.2004.00449.x
The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression, Cell. Microbiol, vol.9, pp.1547-1555, 2007. ,
, ESAT6 inhibits autophagy flux and promotes BCG proliferation through mTOR, 2016.
DOI : 10.1016/j.bbrc.2016.06.042
, Biochem. Biophys. Res. Commun, vol.477, pp.195-201
Reprogramming of the macrophage transcriptome in response to interferon-? and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase, J. Exp. Med, vol.194, pp.1123-1140, 2001. ,
Macrophages and control of granulomatous inflammation in tuberculosis, Mucosal Immunol, vol.4, pp.271-278, 2011. ,
Alternative activation of macrophages: mechanism and functions, Immunity, vol.32, pp.593-604, 2010. ,
Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals, Immunobiology, vol.211, pp.473-486, 2006. ,
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism, PLoS Pathog, vol.7, p.1002251, 2011. ,
BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages, PLoS ONE, vol.7, p.40836, 2012. ,
Forkhead box O3 (FOXO3) transcription factor mediates apoptosis in BCG-infected macrophages, Cell. Microbiol, vol.16, pp.1378-1390, 2014. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01060538
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria, Cell. Microbiol, vol.14, pp.1287-1298, 2012. ,
Mycobacterium tuberculosis-induced polarization of human macrophage orchestrates the formation and development of tuberculous granulomas in vitro, PLoS ONE, vol.10, 2015. ,
Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis, Cell. Microbiol, vol.14, pp.1620-1631, 2012. ,
Emerging trends in the formation and function of tuberculosis granulomas, Front. Immunol, vol.3, p.405, 2013. ,
Macrophage polarization: convergence point targeted by Mycobacterium tuberculosis and HIV, Front. Immunol, vol.2, p.43, 2011. ,
Microdissection of the cytokine milieu of pulmonary granulomas from tuberculous guinea pigs, Cell. Microbiol, vol.9, pp.1127-1136, 2007. ,
Characterization of Mycobacterium tuberculosis EsxA membrane insertion: roles of N-and C-terminal flexible arms and central helix-turn-helix motif, J. Biol. Chem, vol.290, pp.7314-7322, 2015. ,
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system, J. Immunol, vol.15, pp.3570-3579, 2005. ,
The chemokine system in diverse forms of macrophage activation and polarization, Trends Immunol, vol.25, pp.677-686, 2004. ,
Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection, Infect. Immun, vol.83, pp.324-338, 2015. ,
The M1 and M2 paradigm of macrophage activation: time for reassessment, vol.6, p.13, 1000. ,
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome, Cell. Microbiol, vol.12, pp.1046-1063, 2010. ,
Use of proper statistical techniques for research studies with small samples, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.313, pp.873-877, 2017. ,
Modeling the cytokine network in vitro and in vivo, J. Theoret. Med, vol.5, pp.93-110, 2003. ,
Macrophage polarization, Annu. Rev. Physiol, vol.79, pp.541-566, 2017. ,
Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, vol.41, pp.14-20, 2014. ,
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-?, J. Immunol, vol.171, pp.4750-4757, 2003. ,
A new unifying theory of the pathogenesis of tuberculosis, Tuberculosis, vol.94, pp.8-14, 2014. ,
Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages, Nat. Immunol, vol.8, pp.610-618, 2007. ,
Mechanism of ESAT-6 membrane interaction and its roles in pathogenesis of Mycobacterium tuberculosis, Toxicon, vol.116, pp.29-34, 2016. ,
Arginase-1 expression in granulomas of tuberculosis patients, FEMS. Immunol. Med. Microbiol, vol.66, pp.265-268, 2012. ,
Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence, PLoS Pathog, vol.4, p.1000204, 2008. ,
Gene expression profiles of bronchoalveolar cells in pulmonary TB, Tuberculosis, vol.88, pp.39-51, 2008. ,
Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation, J. Leukoc. Biol, vol.88, pp.159-168, 2010. ,
Two distinct conformational states of Mycobacterium tuberculosis virulent factor early secreted antigenic target 6kDa are behind the discrepancy around its biological functions, FEBS J, vol.282, pp.4114-4129, 2015. ,
Foamy macrophages and the progression of the human tuberculosis granuloma, Nat. Immunol, vol.10, pp.943-948, 2009. ,
, Encyclopedia of Measurement and Statistics, vol.1, 2007.
Immune regulatory activities of early secreted antigenic target of 6-kD protein of Mycobacterium tuberculosis and implications for tuberculosis vaccine design, Tuberculosis, vol.91, pp.114-118, 2011. ,
Macrophage polarization in pathology, Cell. Mol. Life Sci, vol.72, pp.4111-4126, 2015. ,
Macrophage plasticity and polarization: in vivo veritas, J. Clin. Invest, vol.122, pp.787-795, 2012. ,
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death, PLoS Pathog, vol.8, p.1002507, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01899479
Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype, Cell Host Microbe, vol.12, pp.669-681, 2012. ,
M. tuberculosis secretory protein ESAT-6 induces metabolic flux perturbations to drive foamy macrophage differentiation, Sci. Rep, vol.5, p.12906, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01378545
Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis, Infect. Immun, vol.63, pp.1710-1717, 1995. ,
The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta2-microglobulin (?2M) affecting antigen presentation function of macrophage, PLoS Pathog, vol.10, p.1004446, 2014. ,
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade, Crit. Rev. Biochem. Mol. Biol, vol.48, pp.375-536, 2008. ,
Origin, kinetics, and characteristics of pulmonary macrophages in the normal steady state, J. Exp. Med, vol.149, pp.1504-1518, 1979. ,
Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium, Science, vol.327, pp.466-469, 2010. ,
Molecular mechanisms that influence the macrophage m1-m2 polarization balance, Front. Immunol, vol.5, p.614, 2014. ,
, Bending the Curve-Ending TB, Annual Report. World Health Organization, 2017.
Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1 interaction, Cell. Physiol. Biochem, vol.35, pp.1276-1288, 2015. ,
Roles and underlying mechanisms of ESAT-6 in the context of Mycobacterium tuberculosis-host interaction from a systems biology perspective, Cell. Signal, vol.24, pp.1841-1846, 2012. ,
Effects of Mycobacterium tuberculosis ESAT-6/CFP-10 fusion protein on the autophagy function of mouse macrophages, DNA Cell Biol, vol.31, pp.171-179, 2012. ,