Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins - Archive ouverte HAL Access content directly
Journal Articles Matrix Biology Year : 2007

Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins

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Abstract

Integrins are essential protagonists in the complex multistep process of cancer progression and metastasis. We recently reported that lebectin, a novel C-type lectin from Macrovipera lebetina venom, displays an anti-integrin activity. In this study, we extend this observation to lebecetin, a second C-type lectin isolated from the same venom and previously reported as a potent inhibitor of platelet aggregation. Both venom lectins appear to exert their effect on cell adhesion, migration, invasion and proliferation by inhibiting α5β1 and αv-containing integrins. Moreover, the inhibition of α5β1 and αv integrins is likely due to the binding of venom peptides, as both lebectin and lebecetin co-immunoprecipitate with these integrins. Lebectin and lebecetin are thus the first examples of venom C-type lectins inhibiting an integrin other than the collagen receptor α2β1.

Dates and versions

pasteur-02024416 , version 1 (19-02-2019)

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Sameh Sarray, Estelle Delamarre, Jacques Marvaldi, Mohamed El Ayeb, Naziha Marrakchi, et al.. Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins. Matrix Biology, 2007, 26 (4), pp.306-313. ⟨10.1016/j.matbio.2007.01.001⟩. ⟨pasteur-02024416⟩
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