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Journal articles
Theileria annulata in CD5(+) macrophages and B1 B cells.
Abstract : Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5(+) clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5(+) B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infections T. annulata can invade and transform CD5(+) B cells.
https://hal-riip.archives-ouvertes.fr/pasteur-02024445
Contributor : Abdelhakim Ben Hassine <>
Submitted on : Tuesday, February 19, 2019 - 10:52:41 AM
Last modification on : Monday, January 13, 2020 - 5:08:14 PM
Contributor : Abdelhakim Ben Hassine <>
Submitted on : Tuesday, February 19, 2019 - 10:52:41 AM
Last modification on : Monday, January 13, 2020 - 5:08:14 PM
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