Skip to Main content Skip to Navigation
New interface
Journal articles

Theileria annulata in CD5(+) macrophages and B1 B cells.

Abstract : Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5(+) clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5(+) B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infections T. annulata can invade and transform CD5(+) B cells.
Complete list of metadata
Contributor : AbdelHakim Ben Hassine Connect in order to contact the contributor
Submitted on : Tuesday, February 19, 2019 - 10:52:41 AM
Last modification on : Friday, August 5, 2022 - 3:04:59 PM

Links full text


  • HAL Id : pasteur-02024445, version 1
  • PUBMED : 10569790



Marie-Françoise Moreau, Jean-Laurent Thibaud, Leila Ben-Miled, Marie Chaussepied, Martin Baumgartner, et al.. Theileria annulata in CD5(+) macrophages and B1 B cells.. Infection and Immunity, 1999, 67 (12), pp.6678-6682. ⟨pasteur-02024445⟩



Record views