W. L. Wagner, P. C. Hoch, and P. H. Raven, Revised classification of the onagraceae, Am Soc Plant Taxon, vol.83, pp.1-240, 2007.

S. S. Dahiya, R. Kaur, and S. K. Sharma, Evaluation of in vitro anthelmintic activity of Oenothera rosea L?Hér. ex Aiton. stem and root, J Nat Prod Plant Res, vol.2, pp.534-543, 2012.

R. Munir, An exploration of phytochemical composition and antioxidant potential of Oenothera rosea

P. Islamabad, , 2016.

M. Budin?evi-c, Z. Vrba-ski, J. Turkulovxyc, and . Dimi-c-e, Antioxidant activity of Oenothera biennis L, Eur J Lipid Sci Technol, vol.97, pp.277-80, 1995.

F. Shahidi, R. Amarowicz, Y. He, and M. Wettasinghe, Antioxidant activity of phenolic extracts of evening primrose (Oenothera biennis): a preliminary study, J Food Lipids, vol.4, pp.75-86, 1997.

M. Hamburger, U. Riese, H. Graf, M. F. Melzig, S. Ciesielski et al., Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities, J Agr Food Chem, vol.50, pp.5533-5541, 2002.

J. Zaugg, O. Potterat, A. Plescher, B. Honermeier, and M. Hamburger, Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose seeds, J Agr Food Chem, vol.54, pp.6623-6631, 2006.

W. Peschel, W. Dieckmann, M. Sonnenschein, and A. Plescher, High antioxidant potential of pressing residues from evening primrose in comparison to other oil seed cakes and plant antioxidants, Ind Crop Prod, vol.25, pp.44-54, 2007.

J. R. Borchardt, D. L. Wyse, C. C. Sheaffer, K. L. Kauppi, R. G. Fulcher et al., Antioxidant and antimicrobial activity of seed from plants of the Mississippi River Basin, J Med Plants Res, vol.3, pp.707-725, 2009.

H. Cronin and Z. D. Draelos, Original contribution: top 10 botanical Ingredients in 2010 anti-aging creams, J Cosmet Dermatol, vol.9, pp.218-243, 2010.

M. S. Marzouk, F. A. Moharram, E. Dib, R. A. El-shenawy, S. M. Tawfike et al., Polyphenolic profile and bioactivity study of Oenothera speciosa Nutt. Aerial parts, Molecules, vol.14, pp.1456-67, 2009.

E. Jaszewska, A. Kosmider, A. K. Kiss, and M. Naruszewicz, Pro-oxidative and pro-apoptotic action of defatted seeds of Oenothera paradoxa on human skin melanoma cells, J Agr Food Chem, vol.57, pp.8282-8291, 2009.

E. Jaszewska, M. Soin, A. Filipek, and M. Naruszewicz, UVA-induced ROS generation inhibition by Oenothera paradoxa defatted seeds extract and subsequent cell death in human dermal fibroblasts, J Photochem Photobiol B Biol, vol.126, pp.42-48, 2013.

A. Ratz-?yko, J. Arct, K. Pytkowska, S. Majewski, and M. Bregisz, Effect of enzymatic hydrolysis on the antioxidant properties of alcoholic extracts of oilseed cakes, Food Technol Biotechnol, vol.51, pp.539-585, 2013.

A. Ahmad, D. K. Singh, K. Fatima, S. Tandon, and S. Luqman, New constituents from the roots of Oenothera biennis and their free radical scavenging and ferric reducing activity, Ind Crop Prod, vol.58, pp.125-157, 2014.

M. Aitani, H. Kimura, Y. Abiru, H. Soyama, H. Murakami et al., Effect of an extract from evening-primrose seeds on postprandial blood glucose level and its active components, Jpn Soc Food Sci Technol, vol.50, pp.180-187, 2003.

A. Ratz-lyko, J. Arct, K. Pytkowska, and S. Majewski, In vivo and ex vivo evaluation of cosmetic properties of seedcakes, J Cosmet Laser Ther, vol.17, pp.109-124, 2015.

S. E. Kim, C. M. Lee, and Y. C. Kim, Anti-melanogenic effect of Oenothera laciniata methanol extract in melan-A cells, Toxicol Res, vol.33, pp.55-62, 2017.

W. L. Li, H. C. Zheng, J. Bukuru, and N. De-kimpe, Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus, J Ethnopharmacol, vol.92, pp.1-21, 2004.

M. Meckes, A. D. David-rivera, V. Nava-aguilar, and A. Jimenez, Activity of some Mexican medicinal plant extracts on carrageenaninduced rat paw edema, Phytomedicine, vol.11, pp.446-51, 2004.

A. Andrade-cetto, Ethnobotanical study of the medicinal plants from Tlanchinol, J Ethnopharmacol, vol.122, pp.163-71, 2009.

M. Zaklos-szyda, I. Majewska, M. Redzynia, and M. Koziolkiewicz, Antidiabetic effect of polyphenolic extracts from selected edible plants as a-amylase, a-glucosidase and PTP1B inhibitors, and bpancreatic cells cytoprotective agents-a comparative study, Curr Top Med Chem, vol.15, pp.2431-2475, 2015.

Y. K. Márquez-flores, H. Montellano-rosales, A. Ma, E. C. , M. Ma et al., Anti-inflammatory activity of aqueous and methanolic extracts of Oenothera rosea L. Hér. ex ait in the rat, Rev Mex Cienc Farm, vol.40, pp.11-17, 2009.

S. Rezapour-firouzi, S. R. Arefhosseini, F. Mehdi, M. Ebrahimimamaghani, B. Baradaran et al., Immunomodulatory and therapeutic effects of hot-nature diet and cosupplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients, Complement Ther Med, vol.21, pp.473-80, 2013.

S. C. Ng, Y. T. Lam, K. Tsoi, F. Chan, J. Sung et al., Systematic review: the efficacy of herbal therapy in inflammatory bowel disease, Aliment Pharmacol Ther, vol.38, pp.854-63, 2013.

W. J. Yoon, Y. M. Ham, B. S. Yoo, J. Y. Moon, J. Koh et al., Oenothera laciniata inhibits lipopolysaccharide induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages, J Biosci Bioeng, vol.107, pp.429-467, 2009.

G. Zeng, Y. Ju, H. Shen, N. Zhou, and L. Huang, Immunopontentiating activities of the purified polysaccharide from evening primrose in H22 tumor-bearing mice, Int J Biol Macromol, vol.52, pp.280-285, 2013.

M. Salaga, U. Lewandowska, D. Sosnowska, P. K. Zakrzewski, A. I. Cygankiewicz et al., Polyphenol extract from evening primrose pomace alleviates experimental colitis after intracolonic and oral administration in mice, Schmiedeb Arch Pharmacol, vol.387, pp.1069-78, 2014.

S. E. Muñoz, M. Piegari, C. A. Guzmán, and A. R. Eynard, Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma, Nutrition, vol.15, pp.208-220, 1999.

A. K. Kiss, A. Filipek, M. Czerwinska, and M. Naruszewicz, Oenothera paradoxa defatted seeds extract and its bioactive component penta-O-galloyl-b-D-glucose decreased production of reactive oxygen species and inhibited release of leukotriene B4, interleukin-8, elastase, and myeloperoxidase in human neutrophils, J Agr Food Chem, vol.58, pp.9960-9966, 2010.

S. Montserrat-de-la-paz, A. Fernandez-arche, M. Angel-martin, and G. Md, The sterols isolated from evening primrose oil modulate the release of proinflammatory mediators, Phytomedicine, vol.19, pp.1072-1078, 2012.

S. Granica, M. E. Czerwinska, J. P. Piwowarski, M. Ziaja, and A. K. Kiss, Chemical composition, antioxidative and anti-inflammatory activity of extracts prepared from aerial parts of Oenothera biennis L. and Oenothera paradoxa hudziok obtained after seeds cultivation, J Agr Food Chem, vol.61, pp.801-811, 2013.

C. D. Pellegrina, G. Padovani, F. Mainente, G. Zoccatelli, G. Bissoli et al., Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis, Cancer Lett, vol.226, pp.17-25, 2005.

E. Jaszewska, A. Kosmider, A. K. Kiss, and M. Naruszewicz, Oenothera paradoxa defatted seeds extract containing pentagalloylglucose and procyanidins potentiates the cytotoxicity of vincristine, J Physiol Pharmacol, vol.61, pp.637-680, 2010.

S. Gorlach, W. Wagner, A. Podsedek, D. Sosnowska, J. Dastych et al., Polyphenols from evening primrose (Oenothera paradoxa) defatted seeds induce apoptosis in human colon cancer caco-2 cells, J Agr Food Chem, vol.59, pp.6985-97, 2011.

U. Lewandowska, K. Owczarek, K. Szewczyk, A. Podsedek, M. Kozio?kiewicz et al., Influence of polyphenol extract from evening primrose (Oenothera paradoxa) seeds on human prostate and breast cancer cell lines, Post?py Hig Med Do sw, vol.68, pp.110-118, 2014.

U. Lewandowska, K. Szewczk, K. Owczarek, Z. Hrabec, A. Podsedek et al., Procyanidins from evening primrose (Oenothera paradoxa) defatted seeds inhibit invasiveness of breast cancer cells and modulate the expression of selected genes involved in angiogenesis, metastasis, and apoptosis, Nutr Cancer, vol.65, pp.1219-1250, 2013.

S. Singh, V. Dubey, D. K. Singh, F. K. Ahmad, A. Luqman et al., Antiproliferative and antimicrobial efficacy of the compounds isolated from the roots of Oenothera biennis L, J Pharm Pharmacol, vol.69, pp.1230-1273, 2017.

V. Insunza, E. Aballay, and J. Macaya, In vitro nematicidal activity of aqueous plant extracts on chilean populations of Xiphinema americanum sensu lato, Nematropica, vol.31, pp.47-54, 2001.

I. Burzynska-pedziwiatr, M. Bukowiecka-matusiak, M. Wojcik, W. Machala, M. Bienkiewicz et al., Dual stimulusdependent effect of Oenothera paradoxa extract on the respiratory burst in human leukocytes: suppressing for Escherichia coli and phorbol myristate acetate and stimulating for formylmethionyl-leucyl-phenylalanine, Oxid Med Cell Longev, p.764367, 2014.

R. Gomez-flores, R. Reyna-martínez, P. Tamez-guerra, and R. Quintanillalicea, Antibacterial activity of Oenothera rosea (L'Hér) leaf extracts, Br J Med Res, vol.2, pp.396-404, 2012.

E. Rock and A. Demichele, Nutritional approaches to late toxicities of adjuvant chemotherapy in breast cancer survivors, J Nutr, vol.133, pp.3785-93, 2003.

M. Fukushima, T. Matsuda, K. Yamagishi, and M. Nakano, Comparative hypocholesterolemic effects of six dietary oils in cholesterol-fed rats after long-term feeding, Lipids, vol.32, pp.1069-74, 1997.

B. Balasinska, Hypocholesterolemic effect of dietary evening primrose (Oenothera paradoxa) cake extract in rats, Food Chem, vol.63, pp.453-462, 1998.

M. A. Villalobos, D. Cruz, J. P. Martin-romero, M. Carmona, J. A. Smith-agreda et al., Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits, Thromb Haemost, vol.80, pp.696-725, 1998.

M. Matsumoto-nakano, K. Nagayama, H. Kitagori, K. Fujita, S. Inagaki et al., Inhibitory effects of Oenothera biennis (evening primrose) seed extract on Streptococcus mutans and S. mutans-induced dental caries in rats, Caries Res, vol.45, pp.56-63, 2011.

A. Oa, Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats, Food Chem Toxicol, vol.35, pp.769-75, 1997.

Y. N. Shukla, A. Srivastava, and S. Kumar, Aryl, lipid and triterpenoid constituents from Oenothera biennis, Ind J Chem, vol.38, pp.705-713, 1999.

S. R. Vargas, S. Zavala, G. C. Pérez, G. Pérez, and G. S. Perez, Preliminary study of antidiarrhoeic activity in five mexican plant species, Phytother Res, vol.12, pp.47-55, 1998.

H. C. Raymond, Aqueous plant extract having antiviral activity. United States Patent US5639460, 1995.

S. Singh, R. Kaur, and S. R. Sharma, An updated review on the Oenothera genus, J Chin Integr Med, vol.10, pp.717-742, 2012.

A. K. Kiss, A. Kaplon-cieslicka, K. J. Filipiak, G. Opolski, and M. Naruszewicz, Ex vivo effects of an Oenothera paradoxa extract on the reactive oxygen species generation and neutral endopeptidase activity in neutrophils from patients after acute myocardial infarction, Phytother Res, vol.26, pp.482-489, 2012.

H. Y. Kim, H. Oh, X. Li, K. W. Cho, D. G. Kang et al., Ethanol extract of seeds of Oenothera odorata induces vasorelaxation via endothelium-dependent NO-cGMP signaling through activation of Akt-eNOS-sGC pathway, J Ethnopharmacol, vol.133, pp.315-338, 2011.

P. Lorenz and F. R. Stermitz, Oxindole-3-acetic acid methylester from the flowers (buds) of Oenothera species, Biochem Syst Ecol, vol.28, pp.189-91, 2000.

S. Schmidt, I. Niklová, J. Pokorný, P. Farka-s, and S. Sekretár, Antioxidant activity of evening primrose phenolics in sunflower and rapeseed oils, Eur J Lipid Sci Technol, vol.105, pp.427-462, 2003.

N. Eskin, Borage and evening primrose oil, Eur J Lipid Sci Technol, vol.110, pp.651-655, 2008.

S. Montserrat-de-la-paz, M. D. García-giménez, M. Ángel-martín, M. C. Pérez-camino, and A. F. Arche, Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages, J Ethnopharmacol, vol.151, pp.131-137, 2014.

T. Krzaczek and A. Bogucka-kocka, P21 chromatographical analysis of phenolic acids in some species genus Oenothera L, Eur J Pharm Sci, vol.2, pp.117-94, 1994.

M. Wettasinghe, F. Shahidi, and R. Amarowicz, Identification and quantification of low molecular weight phenolic antioxidants in seeds of evening primrose (Oenothera biennis L.), J Agr Food Chem, vol.50, pp.1267-71, 2002.

L. Zahradniková, S. Schmidt, Z. Sékelyová, and S. Sekretár, Fractionation and identification of some phenolics extracted from evening primrose seed meal, Czech J Food Sci, vol.26, pp.58-64, 2008.

H. Ntsourankoua and J. Artaud, Determination and identification of triterpenic alcohols in borage, blackcurrant and evening primrose oils, Ol Corp Gras Lipid, vol.4, pp.147-51, 1997.

M. Nogala-kalucka, M. Rudzinska, R. Zadernowski, A. Siger, and I. Krzyzostaniak, Phytochemical content and antioxidant properties of seeds of unconventional oil plants, J Am Oil Chem Soc, vol.87, pp.1481-1488, 2010.

A. K. Kiss and M. Naruszewicz, Polyphenolic compounds characterization and reactive nitrogen species scavenging capacity of Oenothera paradoxa defatted seed extracts, Food Chem, vol.131, pp.485-92, 2012.

R. Knorr and M. Hamburger, Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil, J Agr Food Chem, vol.52, pp.3319-3343, 2004.

A. K. Kiss, M. Derwinska, A. Dawidowska, and M. Naruszewicz, Novel biological properties of Oenothera paradoxa defatted seed extracts: effects on Metallopeptidase activity, J Agr Food Chem, vol.56, pp.7845-52, 2008.

S. Granica, A. Bazylko, and K. Ak, Determination of macrocyclic ellagitannin oenothein B in plant materials by HPLC-DAD-MS: method development and validation, Phytochem Anal, vol.23, pp.582-589, 2012.

T. Yoshida, T. Chou, T. Shingu, T. Okuda, D. Oenotheins et al., dimers from Oenothera laciniata. Phytochemistry, vol.40, pp.555-61, 1995.

S. Granica and A. K. Kiss, Secondary metabolites from aerial parts of Oenothera hoelscheri renner ex rosta nski, Biochem Syst Ecol, vol.44, pp.44-51, 2012.

T. Nakanishi, Y. Inatomi, H. Murata, I. Syun-suke, Y. Fujino et al., Triterpenes and flavonol glucuronides from Oenothera cheiranthifolia, Chem Pharm Bull, vol.55, pp.334-340, 2007.

G. Neumann and B. Schwemmle, Flavonoids from Oenothera-seedlings: identification and extranuclear control of their biosynthesis, J Plant Physiol, vol.142, pp.135-178, 1993.

G. B. Janet, L. Maria, and A. Carlos, Comparative phytochemical research and Oenothera rosea Oenothera multicaulis (Yawar Chonq'a), Situa, vol.9, pp.67-72, 2001.

S. Taniguchi, Y. Imayoshi, R. Yabu-uchi, H. Ito, T. Hatano et al., A macrocyclic ellagitannin trimer, oenotherin T 1 , from Oenothera species, Phytochemistry, vol.59, pp.191-196, 2002.

H. D. Zinsmeister and S. Bartl, The phenolic compounds of Oenothera, Phytochem, vol.10, pp.3129-3161, 1971.

R. Munir, Asian Pac J Trop Biomed, vol.7, issue.11, pp.1046-1054, 2017.

R. Rashid, R. Hameed, M. I. Chaudhary, F. Mukhtar, and A. K. Khan, Antiadipogenic and cytotoxic effects of a new compound from Hartmannia rosea G, Don Curr Pharm Anal, vol.11, pp.300-307, 2015.

N. G. Abdullazhanova and S. M. Mavlyanov, Abdullaev Sh V. Phenolic compounds from Oenothera gigas, Chem Nat Compd, vol.36, pp.97-105, 2000.

J. E. Averet, W. L. Wagner, and S. Huang, The flavonoids of Oenothera sect. megapterium (Onagraceae), Biochem Syst Ecol, vol.19, pp.87-96, 1991.

C. Festa, D. '-auria, M. V. Sepe, V. Ilas, J. Leick et al., Triterpenoid profile and bioactivity study of Oenothera maritima, Phytochem Lett, vol.13, pp.324-333, 2015.

R. Munir, Asian Pac J Trop Biomed, vol.7, issue.11, pp.1046-1054, 2017.