Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.

Nasséra Chalabi; Dominique J Bernard-Gallon; Yves Jean Bignon; Fabrice G Kwiatkowski; M Agier; V. Vidal; V Laplace-Chabaud; Valérie Sylvain-Vidal; Vincent Bertholet; Françoise de Longueville; Marc Lacroix; Guy Leclercq; Josè A Remacle; Catherine Sibille; N Zammateo; N Ben Jaafar; Abdelaziz Sefiani; Karim Ouldim; André Mégarbané; Nadine Jalkh; Wijden Mahfoudh; Wafa Troudi; A. Ben Ammar-El Gaïed; Lotfi Chouchane

Journal articles

Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.

Nasséra Chalabi ^{1, 2} Dominique J Bernard-Gallon ^{1, 2} Yves Jean Bignon ^{1, 3, 2, *} Fabrice G Kwiatkowski ¹ M Agier ^{1, 4} V. Vidal ^{1, 4} V Laplace-Chabaud ^{1, 4} Valérie Sylvain-Vidal ^{1, 4} Vincent Bertholet ⁵ Françoise de Longueville ⁵ Marc Lacroix ⁵ Guy Leclercq ⁵ Josè A Remacle ⁵ Catherine Sibille ⁶ N Zammateo ⁶ N Ben Jaafar ⁷ Abdelaziz Sefiani ⁷ Karim Ouldim ⁷ André Mégarbané ⁸ Nadine Jalkh ⁸ Wijden Mahfoudh Wafa Troudi A. Ben Ammar-El Gaïed Lotfi Chouchane

* Corresponding author

1 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]

2 CRNH d'Auvergne - Centre de Recherche en Nutrition Humaine d'Auvergne

3 UdA - Université d'Auvergne - Clermont-Ferrand I

4 Eppendorf Array Technologies S.A. [Namur]

5 Institut National d'Hygiène [Maroc]

6 USJ - Université Saint-Joseph de Beyrouth

7 Laboratoire d'immunologie clinique [Institut Pasteur de Tunis]

8 Faculté de Médecine de Monastir [Tunisie]

Abstract : BACKGROUND: In Western countries, breast cancer incidence and mortality are higher than in Mediterranean countries. These differences have been ascribed to environmental factors but also to late-stage diagnostic and biological specific characteristics. PATIENTS AND METHODS: Between September 2002 and September 2005, we collected clinical data by phone counselling 180 French and Mediterranean breast cancer patients and performed microarray experiments. RESULTS: Characteristics of breast cancer in patients from Lebanon, Tunisia and Morocco were more aggressive (more SBR grade III and positive node invasion) and patients were 10 years younger at diagnosis. Sixteen differentially expressed genes such as MMP9, VEGF, PHB1, BRCA1, TFAP2C, GJA1 and TFF1 were also found. Additionally, an up-regulation of cytokeratins KRT8 and KRT18 may indicate a luminal B subtype in "South" (Lebanon, Tunisia and Morocco) tumors while "North" (France) tumors may more frequently be luminal A type. CONCLUSION: This study allowed the identification of specific clinical and transcriptomic parameters in patients from South Mediterranean countries.

Keywords : clinical parameters European and Mediterranean countries microarrays Breast cancer

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Journal articles

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Life Sciences [q-bio]

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https://hal-riip.archives-ouvertes.fr/pasteur-02045436
Contributor : Abdelhakim Ben Hassine <>
Submitted on : Friday, February 22, 2019 - 10:02:42 AM
Last modification on : Thursday, June 11, 2020 - 3:20:53 AM

Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.

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Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.

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