A case control study to assess risk factors for hepatitis C among a general population in a highly endemic area of northwest Tunisia.

Nissaf Ben Alaya Bouafif 1, * H. Triki 2 S. Mejri 2 O. Bahri 2 S. Chlif 1 J Bettaib 1 S Héchmi 1 K. Dellagi 3 A. Ben Salah 1
* Corresponding author
1 Laboratoire d'Epidémiologie Médicale, Institut Pasteur de Tunis
2 Institut Pasteur de Tunis
3 Laboratoire d'Immunologie, Institut Pasteur de Tunis
Abstract : A matched case-control study was undertaken in 2004 in Béja, north-western Tunisia, to evaluate potential risk factors for hepatitis C infection. Cases were anti-HCV positive subjects screened in 1996 serosurvey. HCV seronegative controls (5 per case) were selected in the proximity of cases and matched for age and gender. A standardized questionnaire was used to collect demographic, socioeconomic, social behavior, medical and surgical history information. Matched odds ratios (OR) and adjusted OR (AOR) and their 95% CI were calculated in multivariate analysis using logistic regression. 57 HCV positive cases (mean age 61.63 +/- 14,84; 68.4 % female) and 285 HCV negative controls (mean age 60.95 +/- 14.66; 68.4 % female) were enrolled. Multivariate analysis revealed that intravenous drug injections (AOR=1.96; 95%CI[1.02-3.8] p=0.045), past history of invasive procedures (AOR=2.53; 95%CI[1.21-5.29] p=0.0014) and medical history of hypertension (AOR=2.31; 95%CI [1.17-4.56]p=0.015) were significantly associated to HCV infection. These results suggest that nosocomial transmission of HCV infection in north-west Tunisia is common.
Keywords : Hepatitis C viris infection case controls study risk factors epidemiology Tunisia
Document type :
Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-02052120
Contributor : Abdelhakim Ben Hassine <>
Submitted on : Thursday, February 28, 2019 - 12:07:25 PM
Last modification on : Thursday, June 6, 2019 - 1:13:57 AM

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  • HAL Id : pasteur-02052120, version 1
  • PUBMED : 19388580

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Nissaf Ben Alaya Bouafif, H. Triki, S. Mejri, O. Bahri, S. Chlif, et al.. A case control study to assess risk factors for hepatitis C among a general population in a highly endemic area of northwest Tunisia.. Archives de l'Institut Pasteur de Tunis, 2007, 84 (1-4), pp.21-27. ⟨pasteur-02052120⟩

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